AI Article Synopsis
- Researchers created and analyzed copper complexes with the antibacterial drug enrofloxacin and nitrogen donor ligands (1,10-phenanthroline and 2,2'-bipyridine).
- The formation of different types of complexes was observed, including neutral and cationic forms, and their structures were determined using X-ray crystallography.
- The study showed that these complexes effectively bind to DNA and that the Cu(erx)2(H2O) complex exhibits the strongest antimicrobial activity against certain bacteria.
Article Abstract
The mononuclear copper complexes with the quinolone antibacterial drug enrofloxacin (=Herx) in the presence or not of a nitrogen donor heterocyclic ligand 1,10-phenanthroline (=phen) and 2,2'-bipyridine (=bipy) have been prepared and characterized. Interaction of copper(II) with deprotonated enrofloxacin leads to the formation of the neutral complex Cu(erx)2(H2O), 1, while the presence of phen or bipy leads to the formation of a neutral or a cationic mononuclear complex, respectively. The crystal structures of (chloro)(1,10-phenanthroline)(enrofloxacinato)copper(II), 2, and (aqua)(2,2'-bipyridine)(enrofloxacinato)copper(II) chloride, 3, have been determined with X-ray crystallography. The complexes have been studied with X-band electron paramagnetic resonance in aqueous solutions at liquid helium temperature. The study of the interaction of the complexes with calf-thymus DNA has been performed with diverse spectroscopic techniques and has showed that all complexes are bound to DNA by the intercalative mode. The antimicrobial efficiency of the complexes has been tested on three different microorganisms and the available evidence supports that the best inhibition is provided by Cu(erx)2(H2O) (minimum inhibitory concentration=0.125 microg mL(-1)) against Escherichia coli and Pseudomonas aeruginosa.
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| http://dx.doi.org/10.1016/j.jinorgbio.2006.03.013 | DOI Listing |
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