The paper provides the data of an epidemiological survey for acute brain injury in the pediatric population in Nalchik (Republic of Kabardino-Balkaria) during 3 years (1991-1993). The incidence of acute brain injury was 4.32 +/- 0.30, 5.13 +/- 0.34, and 5.44 +/- 0.36 per 1000 children in 2001, 2002, and 2003, respectively, i.e. there is a statistically significant trend for the figures to increase (t = 2.39; p < 0.01). The death of victims was caused by their severe condition and mortality rates were 0.91; those due to brain contusion and compression were 2.68. The paper also presents the structure of victims by the severity of injury and by the differentiation of these parameters by age, and the relationship of craniocerebral traumatism to a number of social factors. Particular emphasis is laid on the quality of specialized aid. The minimum required diagnostic equipment is determined for the correct evaluation of the severity of injury. Algorithms of delivering care to children depending to their age are given, which make the work of an admission department physician easier, reduce the number of diagnostic and therapeutic errors, and promote a reduction in economic costs. The findings enable one to gain an idea of the level of craniocerebral traumatism and to define measures to improve health care.
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Pathogens
December 2024
Pediatric Infectious Disease Unit, Children's Hospital of Parma, 43126 Parma, Italy.
In recent years, an increasing number of reports have described invasive infections caused by bacteria from (SAGs). seems to be more related with pleuropulmonary infections and abscess of the brain and deep soft tissues, and it is more likely to cause suppurative and non-bacteremic infections compared to other members of the same genus. We present two clinical cases of invasive infections in pediatric patients: a liver abscess case and a pansinusitis case associated with bilateral otomastoiditis and parapharyngeal abscess complicated by acute mediastinitis, thrombophlebitis of the cavernous sinus, and thrombosis of the cranial tract of the ipsilateral jugular vein.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Military breachers are routinely exposed to repetitive low-level blast overpressure, placing them at elevated risk for long-term neurological sequelae. Mounting evidence suggests that circulating brain-reactive autoantibodies, generated following CNS injury, may serve as both biomarkers of cumulative damage and drivers of secondary neuroinflammation. In this study, we compared circulating autoantibody profiles in military breachers ( = 18) with extensive blast exposure against unexposed military controls ( = 19).
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Independent Experimental Neuropathophysiology Unit, Chair and Department of Toxicology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland.
The objective of this study is to evaluate the anticonvulsant efficacy of carbamazepine (CBZ) following acute and chronic administration across four treatment protocols in a murine model of maximal electroshock-induced seizures. A single dose of the drug was utilized as a control. The neurotoxic effects were evaluated in the chimney test and the passive avoidance task.
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
Dr. Soetomo General Academic Hospital, Surabaya 60132, Indonesia.
: Although a wide range of hematological parameters are used as blood-based inflammatory biomarkers, the role of complete blood count-derived inflammatory biomarkers in infection after acute ischemic stroke (AIS) is modest. Therefore, this study aimed to explore complete blood count-derived inflammatory biomarkers as predictors of infection after AIS. : A single-center retrospective cross-sectional study was carried out at the National Brain Center Hospital Prof.
View Article and Find Full Text PDFLife (Basel)
December 2024
First Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 106 76 Athens, Greece.
Aquaporins (AQPs) are membrane proteins facilitating water and other small solutes to be transported across cell membranes. They are crucial in maintaining cellular homeostasis by regulating water permeability in various tissues. Moreover, they regulate cell migration, signaling pathways, inflammation, tumor growth, and metastasis.
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