Objective: To explore the relation of syndrome differentiation of zang-and fu-organs with combination of acupoints.

Methods: Relation of syndrome differentiation with combination of shu-yuan points, and combination of he-mu points are analyzed through understanding intension of combination of he-mu points, combination of shu-yuan points and syndrome differentiation, in combination with Prof. WANG fu-chun's clinical experience of m any years.

Results: Combination of he-mu points and combination of shu-yuan points have better therapeutic effect on diseases of zang- and fu-organs.

Conclusion: Combination of he-mu points and combination of shu-yuan points are suitable to treatment of diseases an d syndromes of zang- and fu-organs, and have better therapeutic effects under guidance of syndrome differentiation of zang- and fu-organs, with characteristics of less points selected and easily acceptance for the patients.

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