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Chemo-optogenetic Dimerization Dissects Complex Biological Processes.

Small Methods

January 2025

Laboratory of Chemical Biology and Frontier Biotechnologies, The HIT Center for Life Sciences, Harbin Institute of Technology (HIT), Harbin, 150001, P. R. China.

Light offers superior control in terms of high temporal precision, high spatial precision, and non-invasiveness for the regulation of cellular functions. In recent years, chemical biologists have adopted chemo-optogenetic dimerization approaches, such as photo-triggered chemical inducers of dimerization (pCIDs), as a general tool for spatiotemporal regulation of cellular functions. Traditional chemo-optogenetic dimerization triggers either a single ON or a single OFF of cellular activity.

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Before patients begin out-of-bed exercises following internal fixation surgery for acetabular fractures, turning over in bed serves as a crucial intervention to mitigate complications associated with prolonged bed rest. However, data on the safety of this maneuver post-surgery are limited, and the biomechanical evidence remains unclear. This study aims to introduce a novel loading protocol designed to preliminarily simulate the action of turning over in bed and to compare the biomechanical properties of two fixation methods for acetabular fractures under this new protocol.

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Nutrient acquisition is crucial for sustaining life. Plants develop beneficial intracellular partnerships with arbuscular mycorrhiza (AM) and nitrogen-fixing bacteria to surmount the scarcity of soil nutrients and tap into atmospheric dinitrogen, respectively. Initiation of these root endosymbioses requires symbiont-induced oscillations in nuclear calcium (Ca) concentrations in root cells.

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A balanced activity of cGMP signaling contributes to the maintenance of cardiovascular homeostasis. Vascular smooth muscle cells (VSMCs) can generate cGMP via three ligand-activated guanylyl cyclases, the NO-sensitive guanylyl cyclase, the atrial natriuretic peptide (ANP)-activated GC-A, and the C-type natriuretic peptide (CNP)-stimulated GC-B. Here, we study natriuretic peptide signaling in murine VSMCs and atherosclerotic lesions.

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Preparation of ion imprinted EDTA modified chitosan-magnetic graphene oxide for selective recovery and adsorption mechanism of Ce(III).

Sci Total Environ

January 2025

Inner Mongolia Key Laboratory of Advanced Ceramic Material and Devices, Baotou 014010, China.

Selective recovery of rare earth elements (REEs) from environmental waste is strategically significant. Herein, Ce(III) imprinted EDTA modified chitosan-magnetic graphene oxide (IIP-EDTA-CS-MGO) was prepared for selective recovery of Ce(III). Furthermore, adsorption mechanism was clarified based on versatile adsorption fittings and spectroscopic tests.

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