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Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats.
Front Cell Dev Biol
January 2025
College of Medicine, Central Michigan University, Mount Pleasant, MI, United States.
Introduction: Ischemic stroke is a devastating neurovascular condition that occurs when cerebral tissue fails to receive an adequate supply of oxygen. Despite being a leading cause of death and disability worldwide, therapeutic interventions are currently limited. Polyamidoamine (PAMAM) dendrimers are nanomolecules commonly used in biomedical applications due to their ability to encapsulate small-molecules and improve their pharmacokinetic properties.
View Article and Find Full Text PDFRadiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations.
AJNR Am J Neuroradiol
January 2025
From the Tu Lab for Diagnostic Research, Yale School of Medicine, New Haven, CT, USA (OAZ, AEK, SR) and Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (IDOS, JJ, LHT).
Background And Purpose: Timely reporting of CTA exams impacts management of acute vascular pathology such as large vessel occlusions, arterial dissection, and ruptured aneurysm as well as a variety of acute non-vascular pathologies. In this study, we examine potential modifiable factors impacting the timeliness of CTA reporting performed in stroke code activations.
Materials And Methods: Observational study of stroke code CTA head and neck exams performed at a single health system (3 emergency departments, 1550 inpatient beds) over four years (1/1/2019-12/31/2023).
SDES-YOLO: A high-precision and lightweight model for fall detection in complex environments.
Sci Rep
January 2025
College of Intelligence and Computing, Tianjin University, Tianjin, 300000, China.
Falling is an emergency situation that can result in serious injury or even death, especially in the absence of immediate assistance. Therefore, developing a model that can accurately and promptly detect falls is crucial for enhancing quality of life and safety. In the field of object detection, while YOLOv8 has recently made notable strides in detection accuracy and speed, it still faces challenges in detecting falls due to variations in lighting, occlusions, and complex human postures.
View Article and Find Full Text PDFAMETIS Preplanned Ancillary Study: Impact of Agitation During Mechanical Thrombectomy Under Sedation.
Stroke
February 2025
Anesthésie et Neuro-Réanimation chirurgicale Babinski, Département d'Anesthésie-Réanimation, Assistance Publique Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, France (C.T., R.B., A.J., V.D.).
Article Synopsis
- Mechanical thrombectomy is a common treatment for ischemic strokes, but sedation during the procedure can cause agitation in patients.
- This study, part of the AMETIS research, evaluated patients who experienced agitation and found that 38% had at least one episode during the procedure.
- Although agitation didn’t significantly affect thrombolysis scores or overall outcomes, it did correlate with a higher need for intubation and poorer radiological image quality.
Introduction: Individuals living with sickle cell disease (SCD) commonly report impaired health-related quality of life (HRQoL). However, impacts of SCD on HRQoL and the unmet needs of SCD treatment/management are under-researched. This study characterized the impact of SCD on HRQoL and identified the unmet needs of individuals with SCD.
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