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Malaria parasite detection in Red Blood Cells with rouleaux formation morphology using YOLOv9.
Tissue Cell
December 2024
Department of Electronics and Computer Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310 UTM, Malaysia.
Article Synopsis
- Malaria is common in poor areas and often shows comorbidity with other infections that cause a specific Red Blood Cell deformity called rouleaux formation, which looks like stacked coins.
- The presence of this deformity is important for diagnosing other diseases and is reported by microscopists, especially in malaria patients.
- To enhance malaria diagnostics, a study created a blood smear dataset featuring RBCs with rouleaux formation infected by two malaria species and utilized YOLOv9s architecture to improve detection accuracy of malaria parasites and white blood cells.
Effects of recombinant SARS-CoV-2 spike protein variants on red blood cells parameters and red blood cell distribution width.
Biomed J
December 2024
Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy. Electronic address:
We planned a series of experiments to investigate the possible role of spike protein of different SARS-CoV-2 variants in influencing erythrocyte biology. The values of erythrocyte count, hemoglobin, and mean corpuscular hemoglobin (MHC) did not vary across all samples challenged with both concentrations of the four different SARS-CoV-2 recombinant spike proteins. A significant increase in mean corpuscular volume (MCV) was observed with the recombinant SARS-CoV-2 Alpha and Delta spike proteins at both 2 and 20 ng/mL final concentrations.
View Article and Find Full Text PDFAggregation-prone peptides from within a non-self-protein homoaggregate are preferred for MHC association: Historical overview.
Scand J Immunol
October 2023
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
New technologies assist re-evaluation of hypotheses on generation of immune cell repertoires and distinctions of self from non-self. Findings include positive correlations between peptide propensities to aggregate and their binding to major histocompatibility complex (MHC) proteins. This recalls the hypothesis that foreign proteins may homoaggregate in host cytosols prior to releasing their peptides (p) to form pMHC complexes.
View Article and Find Full Text PDFInk blot leakage in central retinal artery occlusion.
Eur J Ophthalmol
May 2024
Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA.
Purpose: To describe a typical case of acute central retinal artery occlusion (CRAO) with an ink-blot pattern of hyperfluorescent leak on fundus fluorescein angiography (FFA).
Case Description: A 21-year-old woman came to the clinic with one day of painless right eye vision loss. Her right eye had finger counting at ½ meter.
Mid-phase pinpoint hyperfluorescent spots on fundus fluorescein angiography in acute central retinal artery occlusion - a novel imaging finding.
Int J Retina Vitreous
July 2023
Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, 203 Lothrop Street, Suite 800, Pittsburg, PA, 15213, USA.
Purpose: To describe the development and outcome of mid-phase pinpoint hyperfluorescent spots (MPHS) on fundus fluorescein angiography (FFA) in acute (< 7-day symptom onset) central retinal artery occlusion (CRAO) patients.
Methods: This retrospective study included acute CRAO patients who underwent multimodal imaging utilizing optical coherence tomography (OCT) and FFA between June 2017 and January 2023. The correlation of FFA images with the OCT images in various stages and severity of CRAO were studied.
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