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Characterization of Forced Degradants of Tegafur, Gimeracil, and Oteracil Potassium by Liquid Chromatographic-Electrospray Ionization-Mass Spectrometry and Simultaneous Estimation of Triple Combination in Drug Substance and Finished Pharmaceutical Dosage Form.
Arch Razi Inst
April 2024
Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Gandhi Nagar, Rushikonda, Visakhapatnam, Pin code: 530 045, Andhra Pradesh (State), India.
Article Synopsis
- Tegafur, gimeracil, and oteracil potassium are medications used to treat various cancers, including lung cancers and gastrointestinal tract cancers, but no validated methods currently exist for their simultaneous measurement and degradation product analysis.
- This study focuses on developing a robust and efficient liquid chromatography-mass spectrometry (LC-MS) technique, adhering to ICH validation standards, to analyze these drugs together in both the drug substance and finished product.
- The study successfully established detection limits, quantification ranges, and excellent accuracy for the drugs, demonstrating the method's validity with high regression coefficients and low relative standard deviation in replicates.
Knowledge distillation aims to achieve model compression by transferring knowledge from complex teacher models to lightweight student models. To reduce reliance on pre-trained teacher models, self-distillation methods utilize knowledge from the model itself as additional supervision. However, their performance is limited by the same or similar network architecture between the teacher and student.
View Article and Find Full Text PDFBottom-up Histone Post-translational Modification Analysis using Liquid Chromatography, Trapped Ion Mobility Spectrometry, and Tandem Mass Spectrometry.
J Proteome Res
September 2024
Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
The amino acid position within a histone sequence and the chemical nature of post-translational modifications (PTMs) are essential for elucidating the "Histone Code". Previous work has shown that PTMs induce specific biological responses and are good candidates as biomarkers for diagnostics. Here, we evaluate the analytical advantages of trapped ion mobility (TIMS) with parallel accumulation-serial fragmentation (PASEF) and tandem mass spectrometry (MS/MS) for bottom-up proteomics of model cancer cells.
View Article and Find Full Text PDFExploring the Thermal-Oxidative Stability of Azithromycin Using a Thermoactivated Sensor Based on Cerium Molybdate and Multi-Walled Carbon Nanotubes.
Nanomaterials (Basel)
May 2024
Centro de Ciência e Tecnologia, Universidade Federal do Cariri, Av. Tenente Raimundo Rocha, 1639, Cidade Universitária, Juazeiro do Norte 63048-080, CE, Brazil.
The chemical stability of azithromycin (AZM) may be compromised depending on the imposed thermo-oxidative conditions. This report addresses evidence of this process under varying conditions of temperature (20-80 °C), exposure time to UV radiation (1-3 h irradiation at 257 nm), and air saturation (1-3 h saturation with atmospheric air at 1.2 L min and 15 kPa) through electrochemical measurements performed with a thermoactivated cerium molybdate (Ce(MoO))/multi-walled carbon nanotubes (MWCNT)-based composite electrode.
View Article and Find Full Text PDFSystem optimization study of hybrid K-edge/XRF densitometer for uranium-plutonium solution measurement.
Appl Radiat Isot
August 2024
Fundamental Science on Radioactive Geology and Exploration Technology Laboratory, East China University of Technology, Nanchang, 330013, China.
In this paper, a comprehensive hybrid K-edge/XRF densitometer (HKED) device model is constructed using MCNP simulation. After the modeling process, a systematic simulation study is conducted to analyze the physical parameters and material selection of KED and XRF. The simulation results reveal that the optimal parameters for the X-ray tube are an X-ray source voltage of 160 kV and a 1 mm Fe filter.
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