An electroencephalographical survey of 28 healthy children and 87 children with mild types of consequences of CNS perinatal damage has been carried out. The children's age was 1-3 years. The patients have been divided into clinical subgroups as follows: with sleep disorders (24), with myotonic syndrome (20), with general speech underdevelopment (22) and with delayed mental development (21). The results revealed changes in the activity of stem structures as well as of different cortical regions in the groups of children with clinical appearances. Moreover, the data obtained showed specific changes of cross-correlations between cortical regions depending on clinical presentations.
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Biomedicines
December 2024
Institute of Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Dopamine receptors (DRs) are G-protein-coupled receptors (GPCRs) found in the central nervous system (CNS). DRs are essential for mediating various downstream signaling cascades and play a critical role in regulating the dopaminergic nigrostriatal pathway, which is involved in motor control. Recently, mutations in DRD2 (WT), p.
View Article and Find Full Text PDFSmall
January 2025
College of Ecology and Environment, Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, 210037, P. R. China.
Constructing heterojunctions between phase interfaces represents a crucial strategy for achieving excellent photocatalytic performance, but the absence of sufficient interface driving force and limited charge transfer pathway leads to unsatisfactory charge separation processes. Herein, a doping-engineering strategy is introduced to construct a In─N bond-bridged InS nanocluster modified S doped carbon nitride (CN) nanosheets Z-Scheme van der Waals (VDW) heterojunctions (InS/CNS) photocatalyst, and the preparation process just by one-step pyrolysis using the pre-coordination confinement method. Specifically, S atoms doping enhances the bond strength of In─N and forms high-quality interfacial In─N linkage which serves as the atomic-level interfacial "highway" for improving the interfacial electrons migration, decreasing the charge recombination probability.
View Article and Find Full Text PDFAdv Mater
January 2025
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Jiangsu, 210009, P. R. China.
The development of new non-neurotransmitter drugs is an important supplement to the clinical treatment of major depressive disorder. The latest development of mRNA therapy provides the possibility for the treatment of some major diseases. The endoplasmic reticulum (ER) and mitochondria constitute a highly interconnected set of fundamental organelles within cells.
View Article and Find Full Text PDFCurr Pharm Des
January 2025
Maharaja Ranjit Singh Punjab Technical University Pharma Innovation Lab, Department of Pharmaceutical Sciences & Technology Bathinda India.
Aim: The aim of the current study was to explore nano-formulation for effective neuroprotection by auranofin.
Background: Currently, the treatment options for various CNS disorders, particularly neurodegenerative disorders, are greatly constrained. A significant obstacle in this pursuit is the blood-brain barrier, a shielding covering that hinders the route of numerous biochemical treatments into the brain.
Acta Neuropathol Commun
January 2025
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center Unit 1374, 1155 Pressler St, Houston, TX, 77030-3721, USA.
Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characterized by INI1 (SMARCB1) loss. Although metastasis to lungs, lymph nodes, and bone is commonly reported, distant spread to the central nervous system almost never occurs. Here we present an unusual case of a patient with renal medullary carcinoma with metastasis to the brain following treatment which included tazemetostat, an EZH2 inhibitor.
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