AI Article Synopsis
- Assisted reproduction techniques allow for the evaluation of unfertilized oocytes and embryos, revealing a 50% rate of chromosomal abnormalities prior to implantation.
- Two main mechanisms leading to chromosome errors were identified: meiosis non-disjunction and premature separation of sister chromatids, with the latter being particularly prominent in older women and those with recurrent implantation failures.
Article Abstract
In our species, reproduction failure rate is high. Clinical evidence is miscarriage where chromosomal origin was largely involved (66% of cases). The development of assisted reproduction techniques made possible to analyse unfertilized oocytes and preimplantation embryos. The results have shown a high rate of chromosome abnormalities before implantation (50%). Two mechanisms were identified which could generate aneuploidy, the meiosis non-disjunction and the premature separation of sister chromatids (PSSC). A FISH analysis of the first polar body, a cell complementary to the oocyte after meiosis, can be performed before intracytoplasmic sperm injection. We studied 2 distinct populations (patients over 38 years old and patients with recurrent implantation failure) and we confirmed that PSSC is the major mechanism linked to advanced maternal age in human.
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