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Sleep quality in lung cancer and specifically non-small-cell lung cancer: a rapid review.
Support Care Cancer
January 2025
Supportive and Palliative Care Service, Strasbourg University Hospital, Strasbourg Translational Medicine Federation (FMTS), Université de Strasbourg, Strasbourg, France.
Purpose: Sleep quality contributes to the improvement of quality of life in cancer patients. However, sleep disturbances, of variable and heterogeneous etiologies, are common and frequently overlooked in lung cancer patients. The present study undertakes a rapid review of available peer-reviewed literature on sleep quality in lung cancer patients, specifically non-small-cell lung cancer patients.
View Article and Find Full Text PDFLiposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo.
Pharmaceutics
December 2024
Department of Experimental Therapeutics, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Preclinical studies have shown that the anti-malarial drug hydroxychloroquine (HCQ) improves the anti-cancer effects of various therapeutic agents by impairing autophagy. These findings are difficult to translate in vivo as reaching an effective HCQ concentration at the tumor site for extended times is challenging. Previously, we found that free HCQ in combination with gefitinib (Iressa, ZD1839) significantly reduced tumor volume in immunocompromised mice bearing gefitinib-resistant JIMT-1 breast cancer xenografts.
View Article and Find Full Text PDFSpecific Nutrients Mediate the Association of Food Insecurity and Sleep Regularity Index (SRI) in U.S. Adults: NHANES 2011-2014.
Nutrients
January 2025
Translational Biobehavioral and Health Disparities Branch, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Background/objectives: Food-insecure individuals are at risk for poor health outcomes, including substandard sleep health. A possible association of food insecurity with sleep regularity has not been explored, and factors contributing to the relationship between food insecurity and sleep are not well understood. This cross-sectional study explored the relationship between food insecurity and sleep regularity and identified specific nutrients that mediated the association.
View Article and Find Full Text PDFOral Health and Quality of Life in Type 2 Diabetic Patients: Key Findings from a Romanian Study.
J Clin Med
January 2025
Translational and Experimental Clinical Research Centre in Oral Health, Department of Preventive, Community Dentistry and Oral Health, "Victor Babes" University of Medicine and Pharmacy, 300040 Timisoara, Romania.
Diabetes mellitus is associated with various oral health complications that can negatively impact quality of life. Despite evidence of the relationship between diabetes and oral health issues, limited research exists on the perceptions, behaviors, and oral health-related quality of life (OHRQoL) of diabetic patients in Romania. This study aims to evaluate self-reported oral health, knowledge, behaviors, and OHRQoL among diabetic patients in western Romania.
View Article and Find Full Text PDFProteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects.
Molecules
January 2025
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Drug development faces significant financial and time challenges, highlighting the need for more efficient strategies. This study evaluated the druggability of the entire human proteome using Fpocket. We identified 15,043 druggable pockets in 20,255 predicted protein structures, significantly expanding the estimated druggable proteome from 3000 to over 11,000 proteins.
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