AI Article Synopsis
- The study investigated the impact of androgens on bone mineral density (BMD) in men with complete androgen insensitivity (CAI) and 5alpha-reductase-2 deficiency (5alphaRD-2), using data collected from 1989 to 1999.
- Results showed that CAI subjects had significantly lower BMD scores at the lumbar spine and femoral neck compared to 5alphaRD-2 subjects, who exhibited normal BMD values.
- The findings suggest that androgens play a critical role in maintaining BMD, with testosterone and/or low dihydrotestosterone levels being sufficient for this maintenance.
Article Abstract
Context: Subjects with complete androgen insensitivity (CAI) and 5alpha-reductase-2 deficiency (5alphaRD-2) are natural human models to study the direct effect of androgens on bone mineral density (BMD).
Objective: The objective of this study was to test the hypothesis that androgens have a direct effect on BMD in men.
Design: This was a prospective, observational study (1989-1999) using dual energy x-ray absorptiometry.
Setting: The study was set in an outpatient specialty referral center.
Patients Or Other Participants: All known subjects with these conditions (12 CAI and 16 5alphaRD-2) from diverse sociodemographic backgrounds were recruited for the study.
Interventions: There were no interventions.
Main Outcome Measure: Mean Z score and weight-matched Z score at lumbar spine and femoral neck for CAI and 5alphaRD-2 subjects were determined.
Results: Twelve CAI subjects had mean Z score at L2-L4 of -2.84 (+/-0.97, P < 0.001) and a mean weight-matched Z score of -2.52 (+/-0.94, P < 0.001). The mean Z score at the femoral neck was -1.33 (+/-0.91, P < 0.001) and the mean weight-matched Z score was -1.10 (+/-0.82, P = 0.001). Sixteen 5alphaRD-2 subjects had a mean Z score at L2-L4 of -0.84 (+/-1.29, P = 0.02) and a mean weight-matched Z score for 15 of 16 patients of -0.44 (+/-1.08, P = 0.14). The mean Z score at the femoral neck was 0.14 (+/-1.02, P = 0.58) and the mean weight-matched Z score for 15 of 16 patients was 0.49 (+/-0.94, P = 0.06). Therefore, in CAI subjects, BMD was significantly decreased in the spine and hip. 5alphaRD-2 subjects had normal BMD values.
Conclusions: 1) Androgens are of direct importance in the development and/or maintenance of BMD; and 2) testosterone and/or low levels of dihydrotestosterone appear to be sufficient for BMD development and/or maintenance.
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| http://dx.doi.org/10.1210/jc.2005-2809 | DOI Listing |
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