Primary cutaneous lymphomas are characterized by an expansion of hematopoietic cells in the special microenvironment of the skin. They represent a special challenge both for researches and for clinicians who treat patients with these disorders. New research data concerning the biology of lymphocytes and the cutaneous microenvironment have increased our knowledge of these diseases in the last decades. The new WHO/EORTC classification definitely will facilitate a more detailed investigation of the various subtypes.
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Personalized Photoprotection: Expert Consensus and Recommendations From a Delphi Study Among Dermatologists.
Photodermatol Photoimmunol Photomed
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Department of Medicine and Medical Specialties, University of Alcalá de Henares, Madrid, Spain.
Background: Recommending comprehensive personalized photoprotection requires an accurate assessment of the patient's skin, including phototype, lifestyle, exposure conditions, environmental factors, and concomitant cutaneous conditions as well as deep knowledge of the available options: sunscreen ingredients (type of filters, spectrum coverage, sun protection factor, enhanced active ingredients), oral photoprotection, and other methods of sun protection and avoidance.
Objectives: To establish consensus-based recommendations endorsed by an international panel of experts for personalized medical photoprotection recommendations that are applicable globally.
Methods: A two-round Delphi study was designed to determine the degree of agreement and relevance of aspects related to personalized medical photoprotection.
Global Delphi consensus on treatment goals for generalised pustular psoriasis.
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January 2025
Department of Dermatology, Yale University, New Haven, CT, USA.
Background: Generalised pustular psoriasis (GPP) is a chronic, systemic, neutrophilic inflammatory disease. A previous Delphi panel established areas of consensus on GPP, although patient perspectives were not included, and aspects of treatment goals remain unclear.
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Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Lichen planus is a chronic skin lesion characterized by pruritic violaceous papules, which has a high risk of morbidity. Skin microbiota plays an important role in the maintenance of cutaneous mucosal barrier and human health and immune homeostasis. Studies have shown that skin microbiota may play a role in the pathogenesis of lichen planus, but it is not yet clear.
View Article and Find Full Text PDFThe Role and Implications of Epidermal Dysfunction in the Pathogenesis of Inflammaging.
J Invest Dermatol
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Dermatology Hospital of Southern Medical University, Guangzhou, China. Electronic address:
Inflammaging has long been linked to the pathogenesis of various aging-associated disorders, including cardiovascular disease, obesity, type 2 diabetes, and dementia. Yet, the origins of inflammaging remain unclear. Although inflammatory dermatoses such as psoriasis and atopic dermatitis predispose to the development of certain aging-associated disorders, suggesting a pathogenic role of cutaneous inflammation in these disorders, the great majority of aged humans do not have inflammatory dermatoses.
View Article and Find Full Text PDFDisparities in Skin Cancer Outcomes in the Latine/Hispanic Population.
Cutis
November 2024
Dr. Valencia is from the Department of Internal Medicine, John Hopkins Bayview Medical Center, Baltimore, Maryland. Fabiola Ramirez is from the Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso. Claudia Dubocq-Ortiz is from the University of Puerto Rico School of Medicine, Medical School Campus, San Juan. Dr. Vasquez is from the Department of Dermatology, UT Southwestern Medical Center, Dallas.
Article Synopsis
- Latine/Hispanic individuals, while having a lower overall lifetime risk for skin cancer, face higher morbidity and mortality rates in skin cancer outcomes compared to non-Hispanic White individuals.
- Key factors contributing to these disparities include challenges in early detection, limited awareness of risks, and inequitable access to care.
- The article reviews unique clinical features, health coverage issues, medical mistrust, language barriers, and cultural differences, emphasizing the need for better education and equitable treatment strategies.
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