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Cochlear implant electrode design for safe and effective treatment.
Front Neurol
May 2024
Research and Development Department, MED-EL GmbH, Innsbruck, Austria.
The optimal placement of a cochlear implant (CI) electrode inside the scala tympani compartment to create an effective electrode-neural interface is the base for a successful CI treatment. The characteristics of an effective electrode design include (a) electrode matching every possible variation in the inner ear size, shape, and anatomy, (b) electrically covering most of the neuronal elements, and (c) preserving intra-cochlear structures, even in non-hearing preservation surgeries. Flexible electrode arrays of various lengths are required to reach an angular insertion depth of 680° to which neuronal cell bodies are angularly distributed and to minimize the rate of electrode scalar deviation.
View Article and Find Full Text PDFGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
January 2021
Hong Kong Baptist University, School of Chinese Medicine, Hong Kong, China.
Article Synopsis
- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.
The jolly gentle giant titin explains Frank and Starling.
J Mol Med (Berl)
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Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany.
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