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| http://dx.doi.org/10.1371/journal.ppat.0020044 | DOI Listing |
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derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications.
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Henan International Joint Laboratory of Children's Infectious Diseases, Department of Neonatology, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.
is a gram-negative pathogen that can cause multiple diseases including sepsis, urinary tract infections, and pneumonia. The escalating detections of hypervirulent and antibiotic-resistant isolates are giving rise to growing public concerns. Outer membrane vesicles (OMVs) are spherical vesicles containing bioactive substances including lipopolysaccharides, peptidoglycans, periplasmic and cytoplasmic proteins, and nucleic acids.
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January 2025
Department of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, Italy.
The spread of multidrug-resistant microbes has made it necessary and urgent to develop new strategies to deal with the infections they cause. Some of these are based on nanotechnology, which has revolutionized many fields in medicine. Evaluating the safety and efficacy of these new antimicrobial strategies requires testing in animal models before being tested in clinical trials.
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Innate Immunity Group, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
Parasitoid elimination in involves special hemocytes, called lamellocytes, which encapsulate the eggs or larvae of the parasitoid wasps. The capsules are melanized, and metabolites of the melanization reaction may play a potential role in parasitoid killing. We have observed a variation in the melanization capacity of different, commonly used strains, such as Canton-S, Oregon-R, and BL5905, BL6326.
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Molecular and Cellular Microbiology Laboratory, Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
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Cell Host Microbe
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Department of Plant Pathology, University of Georgia, Athens, GA, USA.
The report from Grenz et al. in the latest issue of Cell Host & Microbe demonstrates how incorporation of phenotypic, genetic, genomic, and evolutionary information into experimental design provides a more complete picture than focusing on single host-pathogen relationships.
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