An efficient one-pot procedure for the preparation of 10beta,17beta-dihydroxyestra-1,4-dien-3-one (p-quinol, 1, 75%) is reported, involving oxidation of 17beta-estradiol with potassium permanganate. Similar treatment of 17beta-estradiol with sodium chlorite led to 10beta-chloro-17beta-hydroxyestra-1,4-dien-3-one (2) in 44% yield along with smaller amounts 4-chloro-10beta,17beta-dihydroxyestra-1,4-dien-3-one (3), 2,10beta-dichloro-17beta-hydroxyestra-1,4-dien-3-one (4), and 4,10beta-dichloro-17beta-hydroxyestra-1,4-dien-3-one (5).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.steroids.2006.04.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fluorescence-enhanced detection of sulfide ions through tuning the structure-activity relationship of gold nanoclusters.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control, Department of Environmental Science and Engineering, North China Electric Power University, Baoding 071003, China; Guangdong Provincial Key Laboratory for Green Agricultural Production and Intelligent Equipment, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China. Electronic address:
The concentration of S is a vital environmental indicator for evaluating the quality of source water, surface water, and wastewater, and it has a significant impact on biological systems, particularly human health. Therefore, it is crucial to detect S selectively and sensitively. In this study, we developed a simple and rapid one-pot method to prepare a gold nanocluster (BSA-AuNCs) probe for fluorescence-enhanced detection of S toxemia and analyzed the morphological characteristics of BSA-AuNCs and its complex with S using various characterization techniques.
View Article and Find Full Text PDFCarbon dots with red emission as nanoprobe for sensing of heparin in biofluids and pharmaceutical samples.
RSC Adv
January 2025
Medicinal Plants Research Center, Yasuj University of Medical Sciences Yasuj Iran.
Heparin (HEP) is one of the oldest anticoagulant drugs, widely used in clinical settings, particularly in surgery and dialysis machines. Despite its long history, it remains extensively employed in medical practice. This study introduces a selective and cost-effective method for the rapid detection of HEP using red-emission carbon dots (R-CDs).
View Article and Find Full Text PDFA mechanically robust chitosan-based macroporous foam for sustainable Se(IV) elimination from wastewater.
Carbohydr Polym
March 2025
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China; College of Chemical Engineering and Technology, Yantai Nanshan University, Yantai 265713, China. Electronic address:
The contamination of water resources by selenium (Se), particularly in the highly toxic Se(IV) oxidation state, poses a significant environmental and public health concern due to its detrimental impacts on humans and aquatic ecosystems. In this work, we report a novel composite foam (CFC) by incorporating chitosan (CS), cellulose nanofibers (CNF) and iron oxyhydroxide (FeOOH) nanoparticles through a one-pot fabrication process. The CFC foam features a three-dimensional porous structure, conferring both exceptional mechanical strength and superior adsorption performance for Se(IV), with a maximum equilibrium adsorption capacity of 90 mg/g achieved within 3 h.
View Article and Find Full Text PDFAn ingenious integrated metal-organic frameworks-based ratiometric sensing platform for efficient, sensitive and real-time detection of tetracyclines.
Food Chem
January 2025
School of Public Health, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:
Herein, we report a novel ratiometric nanoprobe (CDs@LZIF-8-Eu) that integrates fluorescent carbon dots (CDs) and Eu on LZIF-8 via a one-pot stirring method. Tetracyclines (TCs) can create inner filter effect on CDs while simultaneously generating an antenna effect with Eu. The rapid and efficient adsorption capabilities of LZIF-8 enhance the probability of TCs interacting with the signal tags.
View Article and Find Full Text PDFVisible-Light-Mediated Cascade 1,4-Hydrogen Atom Transfer versus Dearomative Spirocyclization of -Benzylacrylamides: Divergent Access to Functionalized γ-Ketoamides and 2-Azaspiro[4.5]decanes.
J Org Chem
January 2025
Department of Chemistry, Central University of Punjab, Bathinda 151401, India.
Visible-light-driven metal- and photocatalyst-free cascade 1,4-HAT and dearomative spirocyclization of -benzylacrylamides are described for sustainable synthesis of a variety of pharmaceutically important γ-ketoamides and 2-Azaspiro[4.5]decanes in one pot in good to excellent yields. Readily accessible and nontoxic materials, expensive Ir or Ru photocatalyst-free mild conditions, excellent functional group tolerance, operational simplicity, and scalability enhance the practical value of this protocol.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!