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Validation of the multi-day Boston remote assessment of neurocognitive health (BRANCH) among cognitively impaired & unimpaired older adults.
J Prev Alzheimers Dis
January 2025
Department of Neurology, Brigham and Women's Hospital, Boston, MA, 02115, USA. Electronic address:
Background: The multi-day Boston Remote Assessment of Neurocognitive Health (BRANCH) is a remote, web-based assessment designed to capture the earliest cognitive changes in the preclinical stage of Alzheimer's disease (AD). It has been validated in unimpaired older adults, but as individuals progress on the AD continuum, assessments need to remain feasible and valid at different clinical stages. The focus of this study was to assess feasibility and validity of multi-day BRANCH in participants with and without cognitive impairment.
View Article and Find Full Text PDFWhat are the general public's expectations about the likely duration of common acute infections? A cross-sectional survey of Australian residents.
BMJ Open
December 2024
Institute for Evidence-Based Healthcare, Bond University Ltd, Gold Coast, Queensland, Australia.
Objectives: To explore the general public's expectations about the likely duration of acute infections that are commonly managed in primary care and if care is sought for these infections, reasons for doing so.
Design: A cross-sectional online survey.
Participants: A nationwide sample of 589 Australian residents, ≥18 years old with representative quotas for age and gender, recruited via an online panel provider.
A 5-Year Review of Characteristics and Outcomes of Trauma Surgery Patients Leaving Against Medical Advice.
J Patient Saf
January 2025
Department of Craniofacial and Plastic Surgery, Gillette Children's Hospital, St. Paul, MN.
Objectives: The objective of this study was to characterize the demographic, social, economic, and clinical factors of trauma surgery patients leaving against medical advice (AMA).
Methods: Data were retroactively obtained from a level-one trauma center in a medium-sized metropolitan area from January 2017 to December 2021. The sample population consisted of patients admitted or treated by the trauma surgical service.
Long-term outcome for neoadjuvant versus adjuvant chemotherapy in early breast cancer and the prognostic impact of nodal therapy response: A population-based study.
Eur J Surg Oncol
January 2025
Karolinska Institutet, Oncology/Pathology Department, Stockholm, Sweden; Breast Center, Karolinska Comprehensive Cancer Center, Stockholm, Sweden. Electronic address:
Introduction: Although neoadjuvant systemic treatment for non-metastatic breast cancer has gained ground during the past decade, there is no compelling evidence that it improves overall survival compared to primary tumor resection and adjuvant treatment. At the same time, the approach to responders to neoadjuvant treatment in the axilla is evolving.
Materials And Methods: This is a retrospective analysis of a prospectively collected population-based registry.
Practical Recommendations for the Diagnosis and Management of Lysosomal Acid Lipase Deficiency with a Focus on Wolman Disease.
Nutrients
December 2024
Pediatric Hepatology and Liver Transplant Unit, Department of Pediatrics, ERN Rare Liver ERN TransplantChild, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Lysosomal acid lipase deficiency (LAL-D) is an ultra-rare lysosomal storage disease with two distinct phenotypes, an infantile-onset form (formerly Wolman disease) and a later-onset form (formerly cholesteryl ester storage disease). The objective of this narrative review is to examine the most important aspects of the diagnosis and treatment of LAL-D and to provide practical expert recommendations. The infantile-onset form occurs in the first weeks of life and is characterized by malnourishment and failure to thrive due to gastrointestinal impairment (vomiting, diarrhea, malabsorption), as well as systemic inflammation, hepatosplenomegaly, and adrenal calcifications.
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