Radiopaque lesions and lesions of mixed radioopacity are far less frequent than their radiolucent counterparts. Included in this spectrum are infectious and metastatic disease, inherited and developmental disorders and rare tumoral lesions. This article deals with the imaging features that may assist in the (differential) diagnosis of these lesions. in many instances, the radiological characterization is typical (osteoma, enostoma, fibrous dysplasia, Paget disease...), obviating the need for further invasive histological confirmation. Other lesions may share overlapping clinical, radiological and pathological features. In these cases, correlation of histopathological diagnosis with clinical findings and imaging features is of utmost importance for a correct diagnosis.

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