Tosylated and acetylated imidazolinium salts revealed an unexpected reactivity when treated with methyl iodide or benzyl bromide. Moreover an unprecedented acid-catalysed rearrangement for an acetylated imidazolinium salt was observed during an anion metathesis.
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http://dx.doi.org/10.1039/b601104g | DOI Listing |
Org Biomol Chem
June 2006
Institut für Organische Chemie der Technischen Universität Clausthal, 38678 Clausthal-Zellerfeld, Germany.
Tosylated and acetylated imidazolinium salts revealed an unexpected reactivity when treated with methyl iodide or benzyl bromide. Moreover an unprecedented acid-catalysed rearrangement for an acetylated imidazolinium salt was observed during an anion metathesis.
View Article and Find Full Text PDFDNA Cell Biol
July 1999
Valentis, Inc., Burlingame, California 94010, USA.
As the sequencing of the human genome proceeds, the need for a new screen for in vivo function is becoming apparent. Many investigators are turning to various transgenic models as a means of studying function. However, these approaches are very time consuming, with a transgene-expressing mouse model often taking months to establish.
View Article and Find Full Text PDFJ Pharm Sci
November 1998
Megabios Corporation, 863A Mitten Rd., Burlingame, California 94010, and Southern Research Institute, 2000 Ninth Ave. South, Birmingham, Alabama 35255, USA.
The tissue biodistribution and expression of [33P]DNA-1-[2-[9-(Z)-octadecenoyloxy]ethyl]]-2-[8](Z)-heptadece nyl]-3 -[hydroxyethyl]imidazolinium chloride (DOTIM):cholesterol complexes and 33P-radiolabeled DNA expressing chloramphenicol acetyl transferase (CAT; 4.7 kB) were studied after intravenous (iv) injection in ICR mice. Mice were injected with 200 microL of complex containing DNA at 3 mg/kg or DNA alone.
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