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Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. | LitMetric
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Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

Colin S Osborne Ingrid Leitner Bettina Hofbauer Ceri A Fielding Bertrand Favre Neil S Ryder

Antimicrob Agents Chemother

Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA 02139, USA.

Published: June 2006

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479141PMC
http://dx.doi.org/10.1128/AAC.01600-05DOI Listing

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