Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen.

Florence Doualla-Bell Ava Avalos Tendani Gaolathe Madisa Mine Simani Gaseitsiwe Ndwapi Ndwapi Vladimir A Novitsky Bluma Brenner Maureen Oliveira Daniella Moisi Howard Moffat Ibou Thior Max Essex Mark A Wainberg

Antimicrob Agents Chemother

Botswana-Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone.

Published: June 2006

Among 16 human immunodeficiency virus-infected (subtype C) Batswana patients who failed nelfinavir (NFV)-containing regimens, the most prevalent mutation observed was D30N (54%), followed by L90M (31%). L89I, K20T/I, and E35D polymorphic changes were also identified. These findings suggest that subtype C viruses in Botswana may develop resistance to NFV via subtype-specific pathways.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479146	PMC
http://dx.doi.org/10.1128/AAC.01447-05	DOI Listing

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