Pneumonia can be a life-threatening infection, especially in the elderly, and it is a significant cause of morbidity and mortality. The purpose of this study was to assess the existence of oral infectious pathogens potentially causing the respiratory disease in the dependent elderly. The dental plaques of 138 dependent elderly were examined to identify microorganisms by the culture method. Twenty-one species of microorganisms were detected in the dental plaques in this study. In 89 cases out of 138 (64.5%), potential respiratory pathogens colonized in the dental plaques of the dependent elderly. The results of the present study revealed that bacteria that commonly cause respiratory infection colonized in dental plaques of the aged, dependent subjects. Therefore, dental plaques must be considered a specific reservoir of colonization and subsequent aspiration pneumonia in dependent elderly.
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http://dx.doi.org/10.1016/j.archger.2006.04.004 | DOI Listing |
Ann Gastroenterol Surg
January 2025
The Japanese Society of Gastroenterological Surgery Tokyo Japan.
Aim: This study aimed to evaluate the technical safety and feasibility of gastrectomy for super-elderly patients ≥85-y-old with gastric cancer and to clarify the risk factors for serious postoperative complications in these patients.
Methods: Between 2017 and 2020, 10,203 patients who underwent distal gastrectomy (DG) and 2580 patients who underwent total gastrectomy (TG) were reviewed from the Japanese National Clinical Database. All possible preoperative factors were used to explore the risk factors for serious postoperative complications in the super-elderly patients with gastric cancer.
Heliyon
December 2024
Department of Medicine, Faculty of Medicine and Health Sciences, and Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
In early-stage Alzheimer's disease (AD) amyloid-β (Aβ) deposition can induce neuronal hyperactivity, thereby potentially triggering activity-dependent neuronal secretion of phosphorylated tau (p-tau), ensuing tau aggregation and spread. Therefore, cortical excitability is a candidate biomarker for early AD detection. Moreover, lowering neuronal excitability could potentially complement strategies to reduce Aβ and tau buildup.
View Article and Find Full Text PDFJ Anaesthesiol Clin Pharmacol
April 2024
Department of Anesthesiology, Neurological Institute of Thailand, 312 Ratchawithi Road, Thung Phaya Thai, Ratchathewi, Bangkok, Thailand.
Background And Aims: Control of the hemodynamic response during intubation is essential. To assess the effect of age on the median effective dose (ED50) and 95% effective dose (ED95) of fentanyl for blunting the hemodynamic response to intubation.
Material And Methods: Patients ( = 86) undergoing general anesthesia were randomly stratified according to age (groups 1-4); fentanyl was administered to each patient according to the Dixon and Massey method, starting at 2 μg/kg.
J Inflamm Res
December 2024
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Introduction: Septic arthritis, primarily caused by (), is a severe joint infection that leads to joint and bone damage. lipoproteins (LPPs) bind to Toll-like Receptor 2 (TLR2), inducing arthritis and localized bone loss. Aging affects TLR2 immune response to pathogens.
View Article and Find Full Text PDFFront Psychiatry
December 2024
Psychiatry Department, University of Santiago de Compostela (USC), Santiago de Compostela, A Coruña, Spain.
Introduction: Cognitive impairment and dementia are part of a continuum that progressively leads to functional impairment and dependency. Dementia is a paradigmatic example of chronic and complex psychogeriatric diseases, requiring a comprehensive assessment. The authors underline the importance of implementing a formal assessment of needs (whether met or unmet) as an essential element of comprehensive assessment.
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