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Custom ocular prostheses incorporating braille for a patient with bilateral anophthalmia: A clinical report.
J Prosthet Dent
January 2025
Professor, Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Bilateral anophthalmia, a clinical condition characterized by the absence of globe and ocular tissues from both the orbits, presents considerable challenges to a patient's daily routine and use of prostheses. The patient's inability to orientate custom ocular prostheses (COPs) 3-dimensionally is understandable, and they typically rely on caregivers to manage the prostheses and prevent inadvertent injury to the socket. This clinical report describes the successful integration of braille script into COPs as a solution to these challenges by improving prosthesis management, decreasing caregiver dependence, and encouraging independence.
View Article and Find Full Text PDFDeepening the participation of neurodivergent youth in qualitative mental health research: Co-development of a general approach and the evaluation of its implementation in a study on emotion.
JCPP Adv
December 2024
Department of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.
Background: There is a growing expectation that neurodivergent young people, such as those with diagnoses of attention-deficit/hyperactivity disorder (ADHD) and/or autism, should play a central role in shaping research on neurodevelopmental conditions. However, currently, their involvement is typically limited to arms-length advice. To address this, the (RE-STAR) programme has co-developed a framework for deepening the involvement of neurodivergent participants in translational research.
View Article and Find Full Text PDFBackground: Use of sodium-glucose cotransporter 2 inhibitors (SGLT-2 inhibitors) falls short of their cardiorenal protective benefits. Patient and provider-level barriers hinder the adoption of these life-saving medications. Innovative practices to provide primary care providers (PCPs) with added clinical-decision support via a dedicated remote interdisciplinary diabetes rounds (IDRs) team could promote SGLT-2 inhibitor selection.
View Article and Find Full Text PDFAutomation and miniaturization of high-throughput qPCR for gene expression profiling.
SLAS Technol
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Integrated Genomic Services, Research Department, Sidra Medicine, Doha, Qatar. Electronic address:
Quantitative PCR (qPCR) is a technique commonly employed in laboratories and core facilities. In our previous study, we had shown the possibility to automate steps in a panel-specific gene expression workflow by pairing Mosquito HV with BioMark HD. Here we aimed to automate the full workflow and explore miniaturization capabilities.
View Article and Find Full Text PDFExploring the Therapeutic Potential of 8-Prenyldaidzein: A Comprehensive Study of its Multi-Target Efficacy in Alzheimer's Disease.
Curr Alzheimer Res
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Silicon Script Sciences Private Limited, Bharatpur, Gorahi, Dang, 22400, Nepal.
Background: Alzheimer's disease (AD) is marked by cognitive decline, amyloid plaques, neurofibrillary tangles, and cholinergic loss. Due to the limited success of amyloid-targeted therapies, attention has shifted to new non-amyloid targets like phosphodiesterases (PDE). This study investigates the potential of phytomolecules and derivatives, particularly 8-Prenyldaidzein, in AD treatment.
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