AI Article Synopsis
- The study aimed to assess how modifying titanium implants with acrylic acid and collagen I affects their performance.
- Tests showed that the treated titanium had a porous surface, confirmed by X-ray and electron microscopy.
- Results indicated improved cell growth on collagen-coated surfaces and enhanced bone integration in rabbit femurs, suggesting that this modification could lead to better outcomes in implants.
Article Abstract
The goal of the study was the evaluation of the effect of modification of titanium implants by acrylic acid surface grafting-collagen I coupling. Tests were performed on titanium samples treated by galvanostatic anodization to create a porous surface topography. Surface characterization by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) confirms the biochemical modification of the surface and shows a surface topography characterized by pores mostly below 1 mum diameter. In vitro evaluation involving human mesenchymal cells shows enhanced cell growth on collagen coated surfaces as compared to titanium ones. Four weeks in vivo evaluation of implants in rabbit femur trabecular bone shows improvements of bone-to-implant contact, while improvement of bone ingrowth is slightly not significant (p = 0.056), when compared to the control. Overall, these data indicate that integration in trabecular, or cancellous, bone can be enhanced by the surface collagen layer, confirming previous findings obtained by modification of machined surfaces by the same approach in cortical bone implants.
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| http://dx.doi.org/10.1002/jbm.a.30783 | DOI Listing |
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