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Whole-genome sequencing of non-typeable Haemophilus influenzae isolated from a tertiary care hospital in Surabaya, Indonesia.
BMC Infect Dis
October 2024
Eijkman Research Centre for Molecular Biology, National Research and Innovation Agency, Cibinong, West Java, Indonesia.
Article Synopsis
- - The study investigates the distribution and genetic data of Haemophilus influenzae in hospitalized patients in Surabaya, Indonesia, focusing on its role in severe diseases like septicaemia and meningitis.
- - Researchers used culture-based methods and whole-genome sequencing (WGS) to analyze ten collected isolates, discovering that most were nonvaccine-preventable non-typeable H. influenzae (NTHi) strains.
- - Results identified four new sequence types (STs) and highlighted the presence of significant virulence genes, confirming a diverse population of NTHi in the region compared to global strains.
Optimizing recovery of Haemophilus influenzae from vaginal-rectal specimens and determining carriage rates in pregnant women.
Eur J Clin Microbiol Infect Dis
November 2024
Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, 425 S. Euclid Ave., Campus Box 8118, St. Louis, MO, 63110, USA.
Article Synopsis
- Haemophilus influenzae (HINF), especially the non-typeable strain (NTHi), is a significant cause of neonatal health issues, prompting a study to assess its prevalence in pregnant women.
- The study involved collecting vaginal-rectal swabs from 300 pregnant women during routine screening for Group B Streptococcus, using various methods to optimize the detection of HINF.
- Results showed that while HINF can be efficiently cultured from swabs, its prevalence in pregnant women is low, indicating a need for further investigation into how it may be transmitted to neonates.
The emergence of transposon-driven multidrug resistance in invasive nontypeable Haemophilus influenzae over the last decade.
Int J Antimicrob Agents
October 2024
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
Nontypeable Haemophilus influenzae (NTHi), once considered a harmless commensal, has emerged as a significant concern due to the increased prevalence of multidrug-resistant (MDR) strains and their association with invasive infections. This study aimed to explore the epidemiology and molecular resistance mechanisms of 51 NTHi isolates collected from patients with invasive infections in northern Taiwan between 2011 and 2020. This investigation revealed substantial genetic diversity, encompassing 29 distinct sequence types and 18 clonal complexes.
View Article and Find Full Text PDFTo describe the profile of , identify research gaps, and provide in-depth insights into various aspects related to the pathogen. Google Scholar, PubMed, and ScienceDirect were searched for all studies on the pneumococcus in Ghana that reported on specimen collected, population and sample size, carriage prevalence, incidence of pneumococcal diseases, age of the study population, types of test performed, serotypes identified, antimicrobial susceptibilities, or molecular analysis on the pneumococci for data extraction. Overall, a total of 7954 results were obtained from the three-database search, and of this, 24 articles were selected after screening.
View Article and Find Full Text PDFIn May 2023, the Detroit Health Department was notified of four cases of invasive nontypeable Haemophilus influenzae (Hi) disease among students attending the same elementary school and grade, all with illness onsets within 7 days. Three patients were hospitalized, and one died. Most U.
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