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Anterior Gray Matter Pituicytic Heterotopia with Monomorphic Anterior Pituitary Cells: A Variant of Nonsecretory Pituitary Adenoma Neuronal Choristoma? Report of a Rare Case and Review of the Literature.
World Neurosurg
January 2017
Department of Neurosurgery, Augusta University, Augusta, Georgia, USA.
Article Synopsis
- A rare case of a mixed tumor in the sellar region, potentially a variant of nonsecreting pituitary adenoma neuronal choristoma (PANCH), is reported involving a female with symptoms like headache and blurred vision.
- The surgical removal of the sellar mass revealed heterotopic gray matter with no ganglion cells, and the patient's visual symptoms improved post-operation with no significant growth of the mass during follow-up.
- The study suggests that neuronal choristoma may originate from embryonic pituitary or hypothalamus cells, and emphasizes the importance of surgery as the primary treatment in similar cases.
Pituitary adenoma-neuronal choristoma is a pituitary adenoma with ganglionic differentiation.
Exp Mol Pathol
December 2015
Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital - Weill Cornell Medicine, New York, NY 10065, United States.
The presence of ganglion cells within an endocrine pituitary tumor has been named hamartoma, choristoma, gangliocytoma, or most recently pituitary adenoma-neuronal choristoma (PANCH). The presence of neuronal differentiation in regular pituitary adenomas has been previously suggested, however, its origin, the extent of its presence, and the relationship between the neuronal elements and the pituitary adenoma remain uncertain. Thus, to further explore the neuronal potential of pituitary tumors, we used immunohistochemistry on pituitary tumors of different grades, with a neuronal antigen protein (NeuN) antibody as a specific marker for mature neuronal differentiation.
View Article and Find Full Text PDFPituitary Adenoma Neuronal CHoristoma -- The PANCH syndrome.
Acta Oncol
December 2008
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
Pituitary adenoma-neuronal choristoma (PANCH): cytomorphology on smear preparation.
Cytopathology
June 2006
Department of Pathology and Transfusion Medicine, Sri Sathya Institute of Higher Medical Sciences (SSSIHMS), Bangalore, India.
Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor.
Acta Neuropathol
August 2004
Departments of Pathology, 1G. Gennimatas General Hospital of Athens, KOFKA Building, 1st Floor, 154 Messogion Ave., 115 27, Athens, Greece.
We present a unique case of a prolactin (PRL)-producing pituitary adenoma showing incomplete neuronal differentiation without ganglion cells. A 27-year-old man presented with nausea, headaches, and instability over the last 2 months. Clinical examination revealed obesity with no other endocrinological signs.
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