AI Article Synopsis
- - The study aimed to investigate how ghrelin, a hormone, might influence the development of gallstone disease by comparing 38 patients with gallstones to 112 healthy controls.
- - Results indicated significant differences between the two groups regarding age, body mass index (BMI), and other metabolic factors, with higher ghrelin levels linked to a lower risk of gallstone disease.
- - Overall, findings suggest that higher serum ghrelin concentrations could provide a protective effect against gallstones, as evidenced by a notable presence of ghrelin mRNA in gallbladder samples.
Article Abstract
Aim: To explore the role of ghrelin in gallstone disease.
Methods: We carried out a cross-sectional study in 150 subjects, 38 with gallstones (cases) and 112 controls. We also did a real-time PCR-RT study in twenty gallbladder samples each. Body mass index (BMI), serum insulin, ghrelin, and serum lipids were measured. Logistic regression analyses (univariate and multivariate) were conducted to estimate the probability of gallstone disease associated with serum ghrelin concentrations.
Results: Cases were statistically different from controls in gender distribution (P = 0.01), age (53 vs 44 yr, P = 0.002), BMI (28 vs 25; P = 0.004), and glucose (5.26 vs 4.98 mmol/L; P = 0.05). The prevalence of ghrelin serum levels above the third tercile was lower in subjects without metabolic syndrome (P < 0.05). In a multivariate model, we found a protective effect, when ghrelin values were higher than the median value (OR = 0.27, 95%CI 0.09-0.82, P = 0.02). Twenty (20%) gallbladder specimens expressed ghrelin mRNA.
Conclusion: Serum ghrelin concentrations are associated with a protective effect of GD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124389 | PMC |
| http://dx.doi.org/10.3748/wjg.v12.i19.3096 | DOI Listing |
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