Primary Objective: The Center for Epidemiologic Studies Depression scale (CES-D) is a frequently-used self-report measure of depressive symptom severity. Brief depression screening measures can be important in the identification and prediction of depression following traumatic brain injury. The objective of this study was to investigate the validity of the CES-D in measuring depressive symptoms in patients with mild-to-moderate TBI as it has been rarely used in neurologically compromised populations.
Research Design: Inception cohort.
Methods And Procedures: The CES-D was administered to 340 participants with mild-to-moderate TBI at 3-months post-injury.
Main Outcomes And Results: Confirmatory factor analysis of the CES-D indicated that the data are a reasonable fit similar to that of Radloff 's original 4-factor model.
Conclusions: These findings suggest that the CES-D may be appropriate for use in patients with mild-to-moderate TBI.
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http://dx.doi.org/10.1080/02699050600676651 | DOI Listing |
Biomolecules
January 2025
Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Traumatic brain injury (TBI) is an inflammatory disease causing neurodegeneration. One of the consequences of inflammation is an elevated blood level of fibrinogen (Fg). Earlier we found that extravasated Fg induced an increased expression of neuronal nuclear factor kappa B (NF-κB) p65.
View Article and Find Full Text PDFQuant Imaging Med Surg
December 2024
The First Clinical College, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Background: Cognitive impairment associated with mild-to-moderate chronic traumatic brain injury (TBI) presents substantial challenges for which the functionality of the brain glymphatic system is a key area of interest. This study aimed to explore the functionality of the brain glymphatic system in patients with chronic cognitive impairment following mild-to-moderate TBI using diffusion tensor image analysis along the perivascular space (DTI-ALPS).
Methods: This was a prospective cross-sectional study.
J Neurotrauma
December 2024
Center for Neurologic Studies, Boca Raton, Florida, USA.
Traumatic brain injury (TBI) is frequently associated with hypopituitarism. The hypothalamic-pituitary axis appears to be susceptible to the same forces that cause injury to the parenchyma of the brain. Following even a mild TBI (mTBI), patients may suffer transient or permanent decreases in anterior pituitary hormones, including somatotropin (growth hormone [GH]), gonadotropins (luteinizing hormone and follicle-stimulating hormone), thyrotropin, and adrenocorticotropic hormone, with the most frequent long-term deficiency being GH deficiency (GHD).
View Article and Find Full Text PDFSci Rep
November 2024
Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Traumatic brain injury (TBI) frequently leads to cognitive impairments. The toll-like receptor 4 (TLR4) ligand, Monophosphoryl lipid A (MPL), has shown promise in modulating neuroinflammatory responses after TBI. We investigated the effects of MPL on spatial memory, passive avoidance memory, neuronal survival, and inflammatory/anti-inflammatory cytokines in rat brain following mild-to-moderate TBI.
View Article and Find Full Text PDFNeurosurg Rev
November 2024
Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran.
Brain swelling after Traumatic Brain Injury (TBI) can elevate intracranial pressure, necessitating Decompressive Craniectomy (DC) as the preferred surgical intervention. This study aimed to analyze a large institutional database to identify clinical characteristics of patients requiring primary DC and their outcomes. We reviewed TBI patients admitted to our center from 2015 to 2021, utilizing a prospectively maintained registry.
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