447 patients suffering primary malignant melanoma were registered in the Republic of Tajikistan in 1970-2000. The 1970-1974 morbidity rate of 0.33 rose to 0.51 in 1980-1984 and later fell to 0.07 (1995-2000). Primary tumor localizations were: skin (80.8%), eye (10.9%), and anorectal area (1.8%); primary focus was not identified in 2.9%. A distinction in clinical course was established between native and non-native population. Overall 5-year survival was 56.3%.
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