Monolithic organic polymeric columns for capillary liquid chromatography and electrochromatography.

J Chromatogr B Analyt Technol Biomed Life Sci

Department of Analytical Chemistry, Charles University, Hlavova 2030, 128 40 Prague 2, Czech Republic.

Published: September 2006

This review briefly summarizes the present state of the preparation and use of capillary monolithic columns for liquid chromatography (LC) and electrochromatography (EC). Most important approaches to the preparation of monolithic stationary phases based on organic polymers are outlined and the properties of the monoliths obtained are compared with those of classical particulate phases. A few selected applications of monolithic columns are shown to demonstrate the most important advantages of monolithic capillary columns. It is concluded that both the monolithic and particulate capillary columns are important and that judicious choice of the type suitable for a particular application requires careful consideration of the purpose of the separation and the properties of the solutes to be separated. Monolithic columns are substantially younger than packed ones and thus will require further theoretical and experimental study to further improve their preparation and to enable reliable prediction of their properties and applicability; nevertheless, they are very promising for the future.

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http://dx.doi.org/10.1016/j.jchromb.2006.04.016DOI Listing

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