AI Article Synopsis
- Researchers found that RTVP1 (GLIPR1) is targeted by p53 and has tumor suppressor functions, leading to a search for related genes.
- They identified a gene cluster on human chromosome 12q21 that includes hRTVP-1 and two GLIPR1-like genes (GLIPR1L1 and GLIPR1L2), along with corresponding genes in mice.
- GLIPR1L1 is specific to testis, while GLIPR1L2 is found in several tissues; all three genes are p53 targets, indicating potential similarities in their biological functions.
Article Abstract
Our previous finding of RTVP1 (GLIPR1) as a p53 target gene with tumor suppressor functions prompted us to initiate a genome-wide sequence homology search for RTVP1/GLIPR1-like (GLIPR1L) genes. In this study we report the identification and characterization of a novel p53 target gene cluster that includes human RTVP1 (hRTVP-1) together with two GLIPR1L genes (GLIPR1L1 and GLIPR1L2) on human chromosome 12q21 and mouse Rtvp1 (mRTVP-1 or Glipr1) together with three Glipr1-like (Glipr1l) genes on mouse chromosome 10D1. GLIPR1L1 has two and GLIPR1L2 has five differentially spliced isoforms. Protein homology search revealed that hRTVP-1 gene cluster members share a high degree of identity and homology. GLIPR1L1 is testis-specific, whereas GLIPR1L2 is expressed in different types of tissues, including prostate and bladder. Like hRTVP-1, GLIPR1L1 and GLIPR1L2 are p53 target genes. The similarities of these novel p53 target gene cluster members in protein structure and their association with p53 suggest that these genes may have similar biological functions.
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| http://dx.doi.org/10.1016/j.ygeno.2006.03.021 | DOI Listing |
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