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The dynamics of capillary flow in an open-channel system featuring trigger valves.
Sci Rep
December 2024
Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA.
Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release fluid when there is flow in an orthogonal channel connected to the valve. The concept was originally demonstrated in closed-channel capillary circuits. We show here that trigger valves can be successfully implemented in open channels.
View Article and Find Full Text PDFRapid optical determination of salivary cortisol responses in individuals undergoing physiological and psychological stress.
Sci Rep
December 2024
Research Centre for Biomedical Engineering (RCBE), School of Science and Technology, City, University of London, Northampton Square, London, EC1V 0HB, UK.
Traditional methods for management of mental illnesses in the post-pandemic setting can be inaccessible for many individuals due to a multitude of reasons, including financial stresses and anxieties surrounding face-to-face interventions. The use of a point-of-care tool for self-management of stress levels and mental health status is the natural trajectory towards creating solutions for one of the primary contributors to the global burden of disease. Notably, cortisol is the main stress hormone and a key logical indicator of hypothalamic-pituitary adrenal (HPA) axis activity that governs the activation of the human stress system.
View Article and Find Full Text PDFExploring the Phenomenon of Domestic Violence in Taiwan During the COVID-19 Pandemic: A Complexity Theory Perspective.
J Community Psychol
January 2025
Department of Counseling and Applied Psychology, National Taichung University of Education, Taichung, Taiwan.
The COVID-19 pandemic has been one of the most significant public health events in human history. Domestic violence cases surged globally during the COVID-19 pandemic. In Taiwan, this trend was particularly evident, with a year-over-year increase in reported cases.
View Article and Find Full Text PDFPhotodynamic therapy of cancer-associated infections.
Photochem Photobiol
December 2024
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Pathogens can be involved in tumor initiation, promotion, and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor-prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections and, therefore, has a unique potential to address their combination. However, we believe this potential has been underutilized, and few researchers have investigated the impacts of PDT of both infection-related and cancer-related outcomes at once.
View Article and Find Full Text PDFCENP-E haploinsufficiency causes chromosome misalignment and spindle assembly checkpoint activation in the spermatogonia.
Andrology
December 2024
Department of Cell Biology and Genetics, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, China.
Background: The establishment of kinetochore-microtubule attachment is essential for error-free chromosome alignment and segregation during cell division. Defects in chromosome alignment result in chromosome instability, birth defects, and infertility. Kinesin-7 CENP-E mediates kinetochore-microtubule capture, chromosome alignment, and spindle assembly checkpoint in somatic cells, however, mechanisms of CENP-E in germ cells remain poorly understood.
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