AI Article Synopsis
- Norepinephrine-stimulated skin secretions from the Sante Fe frog contain a peptide called laticeptin with a specific amino acid sequence.
- Laticeptin inhibits the growth of certain Gram-negative bacteria but shows no activity against Gram-positive bacteria.
- Its weak amphipathicity in the alpha-helical structure likely explains its limited antibacterial effects and low hemolytic activity.
Article Abstract
Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys-Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH(2). Laticeptin inhibited the growth of selected Gram-negative bacteria but the lack of activity against Gram-positive bacteria and the very low hemolytic activity is probably a consequence of the weak amphipathicity of the peptide in its alpha-helical conformation.
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| http://dx.doi.org/10.2174/092986606775974410 | DOI Listing |
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