17 salts of ephedrine: crystal structures and packing analysis.

Acta Crystallogr B

Molecular Materials Centre, School of Chemical Engineering and Analytical Science, The University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, England.

Published: June 2006

AI Article Synopsis

  • The study presents the structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine, analyzing their conformations and interactions.
  • The discussion highlights the importance of bilayer formation and how counterions influence structural characteristics.
  • Most salt structures are derived from the packing of the neutral base, with the amphiphilic nature of ephedrine playing a key role, though some larger and more hydrophobic counterions can disrupt this behavior.

Article Abstract

The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour.

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http://dx.doi.org/10.1107/S0108768106012018DOI Listing

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