Efficient and practical synthesis of (R)-2-methylpyrrolidine.

J Org Chem

Department of Process Research, Merck & Company, Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA.

Published: May 2006

An efficient, practical, and high yielding synthesis of (R)-2-methylpyrrolidine is described. The sequence allows for the scalable preparation of the target compound in just four synthetic steps and proceeds in 83% overall yield and >99% optical purity from readily available starting materials.

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http://dx.doi.org/10.1021/jo060319nDOI Listing

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