AI Article Synopsis
- The study aimed to evaluate MMP2 mRNA expression in oral verrucous carcinoma compared to squamous cell carcinoma.
- The research involved 30 cases divided into three groups: verrucous carcinoma, well-differentiated, and moderately/poorly differentiated squamous cell carcinoma, using RT-PCR for analysis.
- Results showed significantly higher MMP2 mRNA levels in carcinomas than in normal tissues, with verrucous carcinoma expressing more than squamous cell types, while no significant difference was found between well-differentiated and poorly differentiated squamous cell carcinomas.
Article Abstract
Objective: To determine the expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma.
Methods: Thirty cases were divided into 3 groups: verruvous carcinoma (n = 10), well-differentiated squamous cell carcinoma (n = 15) and moderately or poorly differentiated squamous cell carcinoma (n = 5). Reverse transcription polymerase chain reaction (RT-PCR) was used to test the expression of MMP2 mRNA in the carcinoma tissues and matched normal tissues from 3 groups above.
Results: The expression of MMP2 mRNA in the carcinoma tissues was significantly higher than that in their matched normal tissues (P < 0.05). The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P < 0.05). However, the expression of MMP2 mRNA was not obviously different between well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P > 0.05).
Conclusion: The expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma tissues was significantly higher than that in their matched normal tissues. The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in squamous cell carcinoma.
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