AI Article Synopsis
- The ACSA Technical Committee has proposed a new method to assess the safety of crop protection chemicals, focusing on scientifically valid studies that assess toxic effects without unnecessary repetition.
- This approach includes a tiered toxicity testing strategy targeting adverse effects on reproduction and development, while also being sensitive to elderly populations.
- Key features of the proposal comprise a novel rat and rabbit study design that reduces animal use, enhances data collection, and evaluates human exposure risks more effectively than current methods.
Article Abstract
A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk assessment. The ACSA Life Stages Task Force proposes a tiered approach to toxicity testing that assesses a compound's potential to cause adverse effects on reproduction, and that assesses the nature and severity of effects during development and adolescence, with consideration of the sensitivity of the elderly. While incorporating many features from current guideline studies, the proposed approach includes a novel rat reproduction and developmental study with enhanced endpoints and a rabbit development study. All available data, including toxicokinetics, ADME data, and systemic toxicity information, are considered in the design and interpretation of studies. Compared to existing testing strategies, the proposed approach uses fewer animals, provides information on the young animal, and includes an estimation of human exposure potential for making decisions about the extent of testing required.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10408440500541367 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
MTSS implementation in residential and day habilitation settings: A scoping review.
J Intellect Disabil
December 2024
Child and Family Studies, University of South Florida, USA.
Although Multi-Tiered Systems of Support (MTSS) has been used in schools, its success has prompted recommendations for its adoption in group home and day habilitation settings. This scoping review examines the literature on implementing MTSS in group home and day habilitation settings for individuals with intellectual and developmental disabilities. Of the 15 studies reviewed, most focused on Positive Behavior Interventions and Supports (PBIS) rather than a comprehensive MTSS framework, raising questions about the alignment of interventions with the three-tiered structure of MTSS.
View Article and Find Full Text PDFBackground: Tobacco taxes are a powerful tool for reducing tobacco consumption and a reliable source of revenue for government.
Aim: To investigate the potential efficacy of tobacco taxation strategies in Jordan in relation to their fiscal and health-related outcomes.
Methods: Using Tobacconomics, we conducted a comparative analysis of several taxation scenarios: maintaining the status quo; increasing both specific excise and tiered taxes; increasing tiered tax rates alone; and raising specific excise taxes only.
Development of a nano-specific safe-by-design module to identify risk management strategies.
Ann Work Expo Health
December 2024
TNO Research Group Risk Analysis for Prevention, Innovation and Development, Princetonlaan 6, PO Box 80015, Utrecht 3584 CB, The Netherlands.
This article describes the development of a Safe-by-Design (SbD) module and its integration into an easy-to-use tool, named the Nano Exposure Quantifier-Safe-by-Design (NEQ-SbD) tool. The NEQ-SbD tool guides its user to lower the exposure to nanomaterials at the worksite where nanomaterials are manipulated or handled during a wide range of activities. This allows the tool user with an informed decision to assess airborne exposure and to select, compare, and identify appropriate risk management measures (RMM).
View Article and Find Full Text PDFStaff perceptions and experiences of using Key Word Signing with children with Down syndrome and their peers in the first year of mainstream primary education.
Int J Lang Commun Disord
December 2024
Department of Speech and Hearing Sciences, University College Cork, Cork, Ireland.
Background: Key Word Signing (KWS) is one system that can be used to support the communication needs of children with Down syndrome (DS) who attend mainstream school. The success of KWS in schools is mediated by staff experiences and perceptions of KWS. The current study is one of the first to explore KWS use in mainstream schools.
View Article and Find Full Text PDFA review on forensic analysis of bio fluids (blood, semen, vaginal fluid, menstrual blood, urine, saliva): Spectroscopic and non-spectroscopic technique.
Forensic Sci Int
December 2024
Department of Science, Alliance University, Bengaluru 562106, India.
The accurate detection, identification, and analysis of biofluids at crime scenes play a critical role in forensic investigations. Various biofluids, such as blood, semen, vaginal fluid, menstrual blood, urine, and saliva, can be crucial evidence. In a murder case involving a knife attack, for instance, bloodstains from both the victim and perpetrator might be present.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!