Remodeling of extracellular matrix is possible due to activity of specific, skilled proteolytic enzymes present in connective tissue. Metalloproteinases (MMPs) are involved most of physiological and pathological processes in human body. To date 28 enzymes have been identified and 23 in humans. This paper is a systemic review of metalloproteinases family. Identification of enzymes in ethiopathogenesis of various diseases is useful in modern therapy planning.
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