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Lack of correlation between asprosin serum levels and hyperphagic behavior in subjects with prader-Willi Syndrome.
J Endocrinol Invest
December 2024
Department of Medical, Movement and Wellbeing Sciences, Parthenope University of Naples, Naples, Italy.
Article Synopsis
- * The study included 118 participants (87 children/adolescents and 31 adults) with PWS, assessing various health metrics, including glucose and cholesterol levels, as well as using a Hyperphagia Questionnaire to measure eating behaviors.
- * Results showed that adults had higher asprosin levels than adolescents, and those with obesity had higher levels than normal-weight individuals, but no significant correlation was found between asprosin and metabolic health indicators;
Background/objectives: Appetitive traits have a central role in energy intake and development of obesity. Child Eating Behavior Questionnaire (CEBQ) is a validated psychometric tool to measure appetitive traits in children. This study sought to assess the CEBQ factor structure in children with obesity.
View Article and Find Full Text PDFIntegrating Genetic Insights, Technological Advancements, Screening, and Personalized Pharmacological Interventions in Childhood Obesity.
Adv Ther
November 2024
University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.
View Article and Find Full Text PDFEating in the Absence of Hunger Is a Stable Predictor of Adiposity Gains in Middle Childhood.
J Nutr
December 2024
Department of Nutritional Sciences, the Pennsylvania State University, University Park, PA, United States; Department of Food Science, The Pennsylvania State University, University Park, PA, United States. Electronic address:
Background: Eating in the absence of hunger (EAH) is a behavioral phenotype of pediatric obesity characterized by the consumption of palatable foods beyond hunger. Studies in children have identified EAH to be stable over time, but findings are unclear on whether it predicts the development of adiposity, particularly in middle childhood, a period of increased autonomy over food choices.
Objectives: We hypothesized that EAH would remain stable and be associated with increased adiposity over a ≥1-y prospective study in 7-8-y old children without obesity.
Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin.
J Cell Physiol
December 2024
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
The proopiomelanocortin (Pomc)-derived peptides, including adrenocorticotropic hormone and α-melanocyte stimulating hormone (α-Msh), play both a central and a peripheral role in modulating the stress response. The central role is predominantly associated with nutrient homeostasis, while peripherally they play an important role in the synthesis of glucocorticoids (GCs) in response to stress. Pomc mutations are a major risk factor in the development of early-onset childhood obesity in humans.
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