[reaction: see text] A strategy for the construction of electron deficient 5,6-aryloxy spiroketal is reported. The process should prove useful for the synthesis of natural products containing similar spiroketals. The strategy uncovers an unexpected rearrangement between ortho and para quinone spiroketals.
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http://dx.doi.org/10.1021/ol0606886 | DOI Listing |
Nat Commun
January 2025
Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Mitochondrial function is modulated by its interaction with the endoplasmic reticulum (ER). Recent research indicates that these contacts are disrupted in familial models of amyotrophic lateral sclerosis (ALS). We report here that this impairment in the crosstalk between mitochondria and the ER impedes the use of glucose-derived pyruvate as mitochondrial fuel, causing a shift to fatty acids to sustain energy production.
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January 2025
Functional Materials Research Laboratory, School of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China.
Polar vortices are predominantly observed within the confined ferroelectric films and the ferroelectric/paraelectric superlattices. This raises the intriguing question of whether polar vortices can form within relaxor ferroelectric ceramics and subsequently contribute to their energy storage performances. Here, we incorporate 10 mol % CaSnO into the 0.
View Article and Find Full Text PDFHistol Histopathol
December 2024
Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, Türkiye.
Iron, a vital element for numerous peripheral and central nervous system functions, is a key player in DNA synthesis, gene expression, myelination, neurotransmission, and mitochondrial electron transport. Iron has utmost importance in various neurological functions, including neurotransmitter synthesis and brain cell metabolism. Migraine is a neurogliovascular disorder in which neuroinflammation plays a crucial role.
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January 2025
Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, West 5th Road, Xi'an, Shaanxi, China.
Peroxiredoxin 6 (PRDX6) is one of the Peroxiredoxin family members with only 1-Cys, using glutathione as the electron donor to reduce peroxides in cells. PRDX6 has been frequently studied and its expression was associated with poor prognosis in many tumors. However, the expression of PRDX6 in multiple myeloma (MM) and its relevance with MM remain unclear.
View Article and Find Full Text PDFTheranostics
January 2025
State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai, China.
White matter has emerged as a key therapeutic target in ischemic stroke due to its role in sensorimotor and cognitive outcomes. Our recent findings have preliminarily revealed a potential link between microglial HDAC3 and white matter injury following stroke. However, the mechanisms by which microglial HDAC3 mediates these effects remain unclear.
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