Molecular biologic techniques have a variety of applications in the study of ischemic heart disease, including roles in elucidating cardiac genetic changes resulting from ischemia as well as in developing therapeutic interventions to treat ischemic heart disease. This review describes recent studies documenting genetic changes associated with myocardial ischemia and infarction as well as those investigating the safety and effectiveness of gene therapy for stimulating angiogenesis, protecting the heart against reperfusion injury, and treating heart failure. Also discussed are future research directions, including the potential use of RNA interference and combined stem cell therapy and gene therapy for the treatment of cardiovascular disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/107424840601100102 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA).
Sci Rep
January 2025
Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.
Myocardial infarction with nonobstructive coronary arteries (MINOCA) constitutes 3-15% of all acute myocardial infarctions. Women are more frequently diagnosed with MINOCA, although the influence of sex on long-term outcomes is still unclear. In this study we aimed to compare sex-based differences in baseline characteristics and clinical outcomes in patients with suspected MINOCA.
View Article and Find Full Text PDFStrength training improves heart function, collagen and strength in rats with heart failure.
J Physiol Sci
January 2025
Experimental Physiology and Biochemistry Laboratory. Physical Education and Sport Center, Federal University of Espirito Santo, Vitoria, Brazil. Electronic address:
Background/objectives: Myocardial infarction (MI) frequently leads to cardiac remodeling and failure with impaired life quality, playing an important role in cardiovascular deaths. Although physical exercise is a well-recognized effective non-pharmacological therapy for cardiovascular diseases, the effects of strength training (ST) on the structural and functional aspects of cardiac remodeling need to be further documented. In this study, we aimed to investigate the role of a linear block ST protocol in the rat model of MI.
View Article and Find Full Text PDFTemporal order of atrial fibrillation and acute myocardial infarction and associated prognosis in the Danish Diet, Cancer and Health cohort.
Open Heart
January 2025
Department of Public Health, Aarhus University, Aarhus, Denmark.
Background: Atrial fibrillation (AF) and acute myocardial infarction (AMI) share risk factors and are bidirectionally associated. Several studies found higher risks of outcomes in individuals with both conditions. Whether the risks of outcomes differ according to temporal order of AF and AMI is unclear.
View Article and Find Full Text PDFThe Role of the Parametric Thyroid Feedback Quantile Index in Cardiovascular Risk Evaluation Among Euthyroid Koreans.
J Clin Endocrinol Metab
January 2025
Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi-do, 18450, South Korea.
Context: Thyroid hormones play a crucial role in metabolic regulation and maintaining cardiovascular homeostasis. The Parametric Thyroid Feedback Quantile-based Index (PTFQI) assesses central thyroid hormone sensitivity by standardizing the inverse relationship between free thyroxine (T4) and thyroid-stimulating hormone (TSH).
Objective: To investigate the relationship between PTFQI and cardiovascular risk in the euthyroid Korean population.
Endovascular therapy and minimally invasive coronary artery bypass grafting for Leriche syndrome with ischaemic heart disease.
Interdiscip Cardiovasc Thorac Surg
January 2025
Department of cardiovascular surgery, Yuuai Medical Center, Okinawa, Japan.
In patients with Leriche syndrome and coronary artery disease, the operative strategy is very important because the internal thoracic artery (ITA) often provides important collateral blood flow to the lower extremities. A 65-year-old man with diabetes mellitus was admitted with heart failure and bilateral claudication. We successfully performed endovascular therapy(EVT) for aortoiliac occlusive disease, followed by minimally invasive coronary artery bypass grafting(MICS-CABG) for ischaemic heart disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!