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| http://dx.doi.org/10.1172/JCI104696 | DOI Listing |
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Cardio-respiratory interactions in acute asthma.
Front Physiol
September 2023
Service de Médecine Intensive Réanimation, Hôpital Robert Debré, Université de Reims, Reims, France.
Asthma encompasses of respiratory symptoms that occur intermittently and with varying intensity accompanied by reversible expiratory airflow limitation. In acute exacerbations, it can be life-threatening due to its impact on ventilatory mechanics. Moreover, asthma has significant effects on the cardiovascular system, primarily through heart-lung interaction-based mechanisms.
View Article and Find Full Text PDFA model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics.
PLoS Comput Biol
January 2018
Department of Pharmacology, University of California, Davis, Davis, CA, USA.
In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type CaV1.2 channels (LTCCs), which trigger the release of calcium (Ca2+) from the sarcoplasmic reticulum (SR). This results in an increase in intracellular Ca2+ (Cai) that initiates contraction.
View Article and Find Full Text PDFMinimal model for calcium alternans due to SR release refractoriness.
Chaos
September 2017
Departament de Física. Universitat Politècnica de Catalunya, Av Dr. Marañon 50 (EPSEB), Barcelona, Spain.
In the heart, rapid pacing rates may induce alternations in the strength of cardiac contraction, termed pulsus alternans. Often, this is due to an instability in the dynamics of the intracellular calcium concentration, whose transients become larger and smaller at consecutive beats. This alternation has been linked experimentally and theoretically to two different mechanisms: an instability due to (1) a strong dependence of calcium release on sarcoplasmic reticulum (SR) load, together with a slow calcium reuptake into the SR or (2) to SR release refractoriness, due to a slow recovery of the ryanodine receptors (RyR2) from inactivation.
View Article and Find Full Text PDFThe value of dynamic preload variables during spontaneous ventilation.
Curr Opin Crit Care
August 2017
Department of Anesthesiology and Intensive Care, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.
Purpose Of Review: To discuss the physiological significance and clinical value of dynamic preload variables in spontaneously breathing patients.
Recent Findings: Dynamic preload variables reflect the response of the cardiac output to a modification of preload and can therefore be used to assess fluid responsiveness. Continuous dynamic parameters that are calculated from the variations in the arterial and plethysmographic waveforms following a mechanical breath have been shown to predict fluid responsiveness much better than static preload parameters.
Aortic Dissection as a Cause of Pulsus Bisferiens: A Case Report and Review.
Ann Vasc Surg
January 2016
Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD.
We present a case of a 62-year-old woman who developed an aortic dissection after aortic valve replacement for aortic stenosis and supracoronary replacement of the ascending aorta for aneurysmal dilation. Dynamic compression of the distal aorta by the dissection flap was identified with the detection of abnormal continuous wave Doppler signals heard while performing ankle-brachial indices. Duplex ultrasound (US) and Doppler spectral waveforms confirmed dynamic compression of the distal aorta with each cardiac cycle.
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