The persisting enigma of AIDS-associated Kaposi's sarcoma: a hypothesis.

The widespread prevalence of Kaposi's sarcoma during the HIV/AIDS epidemic and its unique epidemiological predilection for select groups 'at risk' for AIDS relative to their 'life-style' orientation provide the rationale for etiologic agent(s) other than HIV. In keeping with the requisites for the development and progression of malignancy, i.e., the transformation of normal to aberrant cells and the failure of host defenses to control them, is the rationale, in view of their respective properties, for the hypothesized participation of spermatozoa and/or seminal fluid components as being contributory to the development of Kaposi's sarcoma.