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| http://dx.doi.org/10.1172/JCI101461 | DOI Listing |
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Sea Anemone Kunitz Peptide HCIQ2c1: Structure, Modulation of TRPA1 Channel, and Suppression of Nociceptive Reaction In Vivo.
Mar Drugs
December 2024
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.
TRPA1 is a homotetrameric non-selective calcium-permeable channel. It contributes to chemical and temperature sensitivity, acute pain sensation, and development of inflammation. HCIQ2c1 is a peptide from the sea anemone that inhibits serine proteases.
View Article and Find Full Text PDFImpact of symptomatic multiple sclerosis therapy on pregnancy outcome.
Mult Scler
December 2024
Neurologische Klinik, St. Josef-Hospital, Klinikum der Ruhr-Universität Bochum.
Background: Information on symptomatic therapy (ST) use in women of childbearing age with multiple sclerosis is sparse, and data on the impact of ST pregnancy exposure on pregnancy outcome are lacking.
Objective: To investigate (1) ST use patterns pre-conception, during pregnancy and postpartum and (2) pregnancy outcomes.
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Retromuscular, periprosthetic drainage after hernioplasty with sublay mesh reinforcement in ventral hernias results in less retromuscular fluid collections but longer hospital stay and analgetic use with unclear effect on clinical outcome - a randomized controlled trial.
Langenbecks Arch Surg
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Department of Visceral, General, and Thoracic Surgery, Marienhospital Stuttgart, Stuttgart, Germany.
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Inhaled analgesics for the treatment of prehospital acute pain-A systematic review.
Acta Anaesthesiol Scand
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Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway.
Background: Many prehospital emergency patients receive suboptimal treatment for their moderate to severe pain. Various factors may contribute. We aim to systematically review literature pertaining to prehospital emergency adult patients with acute pain and the pain-reducing effects, adverse events (AEs), and safety issues associated with inhaled analgetic agents compared with other prehospital analgesic agents.
View Article and Find Full Text PDFRelationships between the qNOX, qCON, burst suppression ratio, and muscle activity index of the CONOX monitor during total intravenous anesthesia: a pilot study.
J Clin Monit Comput
December 2024
Department of Anesthesiology and Intensive Care, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Article Synopsis
- The study investigates how different processed EEG indices, specifically qCON (hypnotic level) and qNOX (nociception), interact during propofol anesthesia in patients.
- It finds strong linear relationships among qCON, qNOX, EMG activity, and burst suppression, indicating that these indices can help differentiate the hypnotic and pain-relief aspects of anesthesia.
- A key conclusion is that high qCON levels depend on EMG activity, highlighting potential challenges in detecting wakefulness without EMG, and noting that high opioid doses may affect the relationship between qCON and qNOX.
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