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| http://dx.doi.org/10.1172/JCI100739 | DOI Listing |
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Hemophagocytic Lymphohistiocytosis in a Critically Ill Patient: A Case Report of a Potentially Fatal Entity.
HCA Healthc J Med
December 2024
Oakland University William Beaumont School of Medicine, Rochester Hills, MI.
Background: Hemophagocytic lymphohistiocytosis (HLH) is a non-neoplastic proliferation and macrophage activation that induces cytokine-mediated bone marrow suppression and features of intense phagocytosis in the bone marrow and liver, leading to multi-organ dysfunction and ultimate failure. The diagnosis of HLH in an intensive care setting is challenging, and it is associated with high morbidity and mortality. HLH-94 is the standard protocol for treatment, consisting of dexamethasone and chemotherapy like etoposide.
View Article and Find Full Text PDFPrevention of unplanned extubation in neonatal patients: Protocol for a systematic review and meta-analysis.
PLoS One
January 2025
Faculty of Health Sciences, Postgraduation Program in Health Sciences, University of Brasilia, Brasilia, Brazil.
Unplanned extubation (UPE), defined as accidental removal of the endotracheal tube during mechanical ventilation or its replacement due to suspected obstruction or inadequate diameter, is considered the fourth most common adverse event in neonatal intensive care units (NICU). This study aimed to describe a systematic review and meta-analysis protocol that will identify and assess the effect of primary intervention measures designed to prevent UPE in NICU. A search will be carried out in the following databases: PubMed/Medline, EMBASE, Scopus, CINAHL, Cochrane Library, SciELO, and LILACS.
View Article and Find Full Text PDFPrehospital endotracheal intubation success rates for critical care nurses versus paramedics.
Prehosp Emerg Care
January 2025
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Objectives: Prehospital endotracheal intubation (ETI) is a lifesaving procedure with known complications. To reduce ETI-associated morbidity and mortality, organizations prioritize first-pass success (FPS). However, there are few data evaluating the association of FPS with clinician licensure.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
University of California - San Francisco, San Francisco, CA, USA.
Background: Cholecystectomy is considered the definitive treatment option for cholecystitis, and patients living with Alzheimer's Disease and Related Dementias (PLWDs) are at risk for increased mortality, complications, and delirium. However, the effect of different treatment options for cholecystitis among PLWDs has not been elucidated; therefore, this study compares outcomes following cholecystectomy, cholecystostomy tube, and medical management of cholecystitis among this high-risk group.
Method: We conducted a retrospective analysis of Medicare claims data from 1/1/2016-12/31/2020.
Validation of Pediatric Sequential Organ Failure Assessment (pSOFA) Scores to Predict Critical Events in the Pediatric Intensive Care Unit.
J Intensive Care Med
January 2025
Division of Critical Care Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Objective: To determine the prognostic value of the Pediatric Sequential Organ Failure Assessment (pSOFA) to discriminate critical events, including code events and intubations, in the pediatric intensive care unit (PICU).
Methods: We performed an observational cohort study of all critical events in a quaternary care PICU between 5/2020 and 4/2023. Critical events were extracted from our hospital communications platform and from the electronic health record (EHR).
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