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| http://dx.doi.org/10.1172/JCI100613 | DOI Listing |
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N-glycosylation in the SERPIN domain of C1-Esterase Inhibitor in hereditary angioedema.
JCI Insight
January 2025
Medicine, Washington University School of Medicine, St. Louis, United States of America.
Hereditary angioedema is an autosomal dominant disorder caused by defects in C1-esterase inhibitor (C1-INH), resulting in poorly controlled activation of the kallikrein-kinin system and bradykinin overproduction. C1-INH is a heavily glycosylated protein in the serine protease inhibitor (SERPIN) family, yet the role of these glycosylation sites remains unclear. To elucidate the functional impact of N-glycosylation in the SERPIN domain of C1-INH, we engineered four sets consisting of 26 variants at or near the N-linked sequon (NXS/T).
View Article and Find Full Text PDFWoody species diversity, structure and community distribution along environmental gradients of Seqela Dry Afromontane forest in Northwestern Ethiopia.
PLoS One
January 2025
School of Geography, Geology and the Environment, Institute for Environmental Futures, University of Leicester, Leicester, United Kingdom.
Dry evergreen Afromontane forests are severely threatened due to the expansion of agriculture and overgrazing by livestock. The objective of this study was to investigate the composition of woody species, structure, regeneration status and plant communities in Seqela forest, as well as the relationship between plant community types and environmental variables. Systematic sampling was used to collect vegetation and environmental data from 52 (20 m x 20 m) (400 m2) plots.
View Article and Find Full Text PDFCharacterizing the within-person variability of food insecurity in everyday life.
PLoS One
January 2025
Department of Psychology, The Ohio State University, Columbus, Ohio, United States of America.
Food insecurity (FI), the lack of access to adequate food, is linked with negative health and psychological outcomes. FI is typically measured retrospectively over the last year; although this measurement is useful to understand FI prevalence to inform broad policy, it leaves the experience of FI in everyday life poorly understood. Understanding how FI varies across shorter periods of time (days or weeks) can help inform FI prevention and/or intervention.
View Article and Find Full Text PDFAdolescent reports of subjective socioeconomic status: An adequate alternative to parent-reported objective and subjective socioeconomic status?
PLoS One
January 2025
Department of Psychology and Neuroscience, Duke University, Durham, North Carolina, United States of America.
Socioeconomic status (SES) is associated with well-being outcomes across studies; however, there is wide variation in its measurement, particularly in adolescence. One key difference in measures of SES concerns whether participants relay objective information-for example, years of education, household income-or subjective perceptions of socioeconomic status, either with or without reference to others or society. Although parents are often considered the best source of SES information-especially objective SES-within families, interviewing parents within the context of adolescent research is costly, time-consuming, and not always feasible.
View Article and Find Full Text PDFAssessing the capture of sociodemographic information in electronic medical records to inform clinical decision making.
PLoS One
January 2025
Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada.
There is a growing need to document sociodemographic factors in electronic medical records to produce representative cohorts for medical research and to perform focused research for potentially vulnerable populations. The objective of this work was to assess the content of family physicians' electronic medical records and characterize the quality of the documentation of sociodemographic characteristics. Descriptive statistics were reported for each sociodemographic characteristic.
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