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Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis.
Eur Respir Rev
October 2024
Respiratory Medicine, Allergology and Palliative Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Article Synopsis
- People with serious respiratory illnesses often face distressing symptoms, and while opioids are commonly prescribed for relief, their effectiveness and potential side effects are in question.
- A review of 17 trials showed that opioids did reduce breathlessness during exercise in controlled lab settings, but they had little impact on daily breathlessness, cough, or overall quality of life.
- The use of opioids was associated with increased occurrences of adverse effects like nausea, constipation, and drowsiness, along with serious risks such as hospitalization and death.
Krukenberg tumor arising from gastric cancer presenting as Pseudo-Meigs' syndrome: a case report and literature review.
Front Med (Lausanne)
September 2024
Department of Gynecology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- Krukenberg tumor is a rare type of ovarian cancer that often shows up with symptoms like abdominal pain and swelling, commonly due to both ovaries being affected.
- The case study discusses a 39-year-old woman who experienced unusual symptoms like abdominal distension and shortness of breath, leading to the discovery of the tumor.
- The tumor was confirmed to be signet ring cell carcinoma, and it was associated with Pseudo-Meigs' syndrome, highlighting the importance for doctors to consider this syndrome in similar cases for potential effective treatment.
An 86-year-old woman with leg edema and dyspnea on exertion was admitted to our hospital. Chest computed tomography (CT) revealed a mass in the anterior mediastinum with pericardial invasion. Histological examination with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) led to the diagnosis of Masaoka stage IVa type B2 thymoma.
View Article and Find Full Text PDFThoracic Society of Australia and New Zealand clinical practice guideline on adult home oxygen therapy.
Respirology
September 2024
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia.
This Thoracic Society of Australia and New Zealand Guideline on the provision of home oxygen therapy in adults updates a previous Guideline from 2015. The Guideline is based upon a systematic review and meta-analysis of literature to September 2022 and the strength of recommendations is based on GRADE methodology. Long-term oxygen therapy (LTOT) is recommended for its mortality benefit for patients with COPD and other chronic respiratory diseases who have consistent evidence of significant hypoxaemia at rest (PaO2 ≤ 55 mm Hg or PaO2 ≤59 mm Hg in the presence of hypoxaemic sequalae) while in a stable state.
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