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Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes.
Int J Dermatol
December 2024
HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary.
Background: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem.
Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.
Image-enhanced endoscopy in upper gastrointestinal disease: focusing on texture and color enhancement imaging and red dichromatic imaging.
Clin Endosc
November 2024
Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Endoscopic examination plays a crucial role in the diagnosis of upper gastrointestinal (UGI) tract diseases. Despite advancements in endoscopic imaging, the detection of subtle early cancers and premalignant lesions using white-light imaging alone remains challenging. This review discusses two novel image-enhanced endoscopy (IEE) techniques-texture and color enhancement imaging (TXI) and red dichromatic imaging (RDI)-and their potential applications in UGI diseases.
View Article and Find Full Text PDFEvaluation of factors associated with immunoglobulin, protein, fat and lactose concentrations in colostrum of dairy cows from Austria.
Acta Vet Scand
December 2024
Clinical Department for Farm Animals and Food System Science, Clinical Center for Ruminant and Camelid Medicine, University of Veterinary Medicine Vienna, Veterinaerplatz 1, Vienna, 1210, Austria.
Background: Calves rely on the passive transfer with immunoglobulins derived from colostrum. Currently, there is a lack of knowledge on colostrum management practices and colostrum quality on small scale family-owned dairy farms in Austria. The objectives of this study were to describe factors that are associated with immunoglobulin, protein, fat and lactose concentrations in dairy cow colostrum from the federal state of Salzburg.
View Article and Find Full Text PDFThe "uneven road" to food: Socioeconomic disparities in the mobility burden of food purchasing behavior in major US cities, 2019-2023.
Health Place
December 2024
School of Architecture, Georgia Institute of Technology, United States. Electronic address:
Socioeconomic factors contribute to distinct patterns of food-purchasing behaviors, placing a higher burden of mobility on vulnerable, deprived populations. Traditional approaches often overlook the dynamics of human activity as contextual influences, simulating a perceived food environment that contradicts the actual use thereof. The rise of large-scale mobile phone data presents a unique opportunity to capture real behavioral patterns and their mobility implications at a fine-grained level.
View Article and Find Full Text PDFName avoidance in social anxiety: Understanding alexinomia.
J Anxiety Disord
December 2024
Association for Psychotherapy, Counselling, Supervision and Group Facilitation, Vienna, Austria; Institute for Person-Centered Studies, Vienna, Austria.
Emerging evidence suggests that certain individuals are unable to address others by name, presumably owing to anxiety experienced in social situations. This fear of using personal names has been termed alexinomia and occurs in all forms of relationships and communication. The symptoms of alexinomia show large overlap with the symptoms typically associated with social anxiety, raising the question of whether social anxiety could be the main driving factor of this type of name avoidance.
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