AI Article Synopsis
- The study presents new findings on where digestive enzymes are located in different layers of the small intestine in rats.
- It proposes a hypothesis that, in addition to the enzyme complex on the surface of epithelial cells, there is a secondary barrier made up of enzymes in subepithelial structures.
- The effectiveness of this second barrier was demonstrated through experiments involving peptide breakdown and transport in intact and de-epithelialized sections of the intestine.
Article Abstract
Proceeding from the newly obtained evidence on the distribution of digestive enzymes in mucosal, submucosal and muscular layers of the small intestine in rats, a hypothesis has been formulated: in addition to the enterocyte enzyme complex forming the epithelial barrier, there seems to exist a postepithelial barrier formed by the enzymes localized in subepithelial structures. The efficiency of this second barrier was manifested by the study of the peptide hydrolysis and transport using everted intact and de-epithelialized intestinal sacs.
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