Matching 3D shapes is important in many medical imaging applications. We show that a joint clustering and diffeomorphism estimation strategy is capable of simultaneously estimating correspondences and a diffeomorphism between unlabeled 3D point-sets. Correspondence is established between the cluster centers and this is coupled with a simultaneous estimation of a 3D diffeomorphism of space. The number of clusters can be estimated by minimizing the Jensen-Shannon divergence on the registered data. We apply our algorithm to both synthetically warped 3D hippocampal shapes as well as real 3D hippocampal shapes from different subjects.
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http://dx.doi.org/10.1007/11566489_121 | DOI Listing |
Nat Metab
January 2025
Monell Chemical Senses Center, Philadelphia, PA, USA.
The hippocampus (HPC) has emerged as a critical player in the control of food intake, beyond its well-known role in memory. While previous studies have primarily associated the HPC with food intake inhibition, recent research suggests a role in appetitive processes. Here we identified spatially distinct neuronal populations within the dorsal HPC (dHPC) that respond to either fats or sugars, potent natural reinforcers that contribute to obesity development.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum 44780, Germany.
The novelty, saliency, and valency of ongoing experiences potently influence the firing rate of the ventral tegmental area (VTA) and the locus coeruleus (LC). Associative experience, in turn, is recorded into memory by means of hippocampal synaptic plasticity that is regulated by noradrenaline sourced from the LC, and dopamine, sourced from both the VTA and LC. Two persistent forms of synaptic plasticity, long-term potentiation (LTP), and long-term depression (LTD) support the encoding of different kinds of spatial experience.
View Article and Find Full Text PDFIndividual choices shape life course trajectories of brain structure and function beyond genes and environment. We hypothesized that individual task engagement in response to a learning program results in individualized learning biographies and connectomics. Genetically identical female mice living in one large shared enclosure freely engaged in self-paced, automatically administered and monitored learning tasks.
View Article and Find Full Text PDFCogn Affect Behav Neurosci
January 2025
Department of Psychology, Brandeis University, Waltham, MA, USA.
Culture can shape memory, but little research has investigated age effects. The present study examined the neural correlates of memory retrieval for old, new, and similar lures in younger and older Americans and Taiwanese. A total of 207 participants encoded pictures of objects and, during fMRI scanning, completed a surprise object recognition task testing discrimination of similar and new from old items.
View Article and Find Full Text PDFElife
January 2025
Department of Neurology, Baylor College of Medicine, Houston, United States.
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