This paper presents a novel approach for image segmentation by introducing competition between neighboring shape models. Our method is motivated by the observation that evolving neighboring contours should avoid overlapping with each other and this should be able to aid in multiple neighboring objects segmentation. A novel energy functional is proposed, which incorporates both prior shape information and interactions between deformable models. Accordingly, we also propose an extended maximum a posteriori (MAP) shape estimation model to obtain the shape estimate of the organ. The contours evolve under the influence of image information, their own shape priors and neighboring MAP shape estimations using level set methods to recover organ shapes. Promising results and comparisons from experiments on both synthetic data and medical imagery demonstrate the potential of our approach.
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http://dx.doi.org/10.1007/11566465_34 | DOI Listing |
Med Phys
January 2025
Breast Imaging Department, Red Cross Hospital Munich, Munich, Germany.
Background: A significant proportion of false positive recalls of mammography-screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth-shaped dense masses and require the recalling of women for a breast ultrasound to obtain complementary imaging information. They can be identified safely by ultrasound with no need for further assessment or treatment.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: African Americans (AA) are disproportionally burdened by Alzheimer's disease (AD), but there is a scarcity of research focusing on understanding the neuroimmune component of AD pathogenesis in this population. It is generally accepted that microglia would be an ideal therapeutic target for AD and that genetic, lifestyle, societal and environmental factors and stressors have the potential to shape microglia phenotypes and their contribution to neurodegenerative processes. The overarching goal of the current study is to establish the population structure of microglia in older AAs and to investigate the relationship of the different microglia subsets with histopathological hallmarks of brain aging and AD in AAs.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Center for Translational & Computational Neuroimmunology, Columbia University Irving Medical Center, New York, NY, USA.
Background: Stage III activated microglia have been associated with Alzheimer's Disease (AD) and cognitive decline. Separately, recent single-cell RNA-sequencing revealed CD74 as a marker gene that is enriched in immunologically active microglial subtypes associated with AD.
Method: Post mortem tissue sections from the dorsolateral prefrontal cortex were stained simultaneously for (1) CD74, (2) IBA1 (a general microglial marker that outlines cellular processes), and (3) phosphoTau (AT8 antibody) to locate Tau proteinopathy.
Alzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Employing a custom 60-channel single-transmit/32-channel receive Tic-Tac-Toe (TTT) coil in 7T MRI imaging has enhanced the resolution and contrast for identifying White Matter Hyperintensities (WMHs), which are critical markers in Alzheimer's disease and related dementias (AD/ADRD).
Method: The method involves resecting the left hemisphere of the brain, excluding the cerebellum, followed by embalming in 10% formalin. 1.
Front Plant Sci
December 2024
Center for Precision and Automated Agricultural Systems, Department of Biological Systems Engineering, Washington State University, Prosser, WA, United States.
Molecular-based detection of pathogens from potato tubers hold promise, but the initial sample extraction process is labor-intensive. Developing a robotic tuber sampling system, equipped with a fast and precise machine vision technique to identify optimal sampling locations on a potato tuber, offers a viable solution. However, detecting sampling locations such as eyes and stolon scar is challenging due to variability in their appearance, size, and shape, along with soil adhering to the tubers.
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